Synovial sarcoma in knee joint, mimicking low-grade sarcoma confirmed by molecular detection of SYT gene split.
Synovial sarcoma in knee joint, mimicking low-grade sarcoma confirmed by molecular detection of SYT gene split.
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发表时间：
2014-06
影响因子：
2
通讯作者：
H. Kimura;N. Yamamoto;H. Nishida;K. Hayashi;A. Takeuchi;T. Nojima;H. Ikeda;Seiko Sawada‐Kitamura;H. Tsuchiya
中科院分区：
文献类型：
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作者：
H. Kimura;N. Yamamoto;H. Nishida;K. Hayashi;A. Takeuchi;T. Nojima;H. Ikeda;Seiko Sawada‐Kitamura;H. Tsuchiya
摘要一位十岁男童因膝关节内肿块而接受关节镜下刮除术。肿瘤被诊断为低度恶性纤维肉瘤。5年后，患者出现肿瘤复发。患者接受了保留膝关节的边缘切除术，未接受辅助治疗。最后一次手术后两年，患者正在茁壮成长，没有复发或转移性疾病的证据。最终诊断为滑膜肉瘤，通过荧光原位杂交（FISH）进行SYT基因分裂证实，尽管肿瘤在苏木精-伊红切片中显示为低级别纤维型。第一个刮除的标本也被证实携带SYT基因分裂。滑膜肉瘤通常被认为是一种高度恶性的肉瘤。我们的病人有一个肿瘤，表现出组织学和临床低级别肿瘤的特点。从目前的情况下，我们认为，低级别的变种滑膜肉瘤确实存在，虽然他们的存在仍然存在争议。
A 10-year-old boy underwent arthroscopic curettage for an intra-articular mass in knee joint. The tumor was diagnosed as low-grade fibrous sarcoma. Five years later, the patient presented with a recurrent tumor. The patient underwent a marginal excision with knee joint preservation and without adjuvant therapy. Two years after the last surgery, the patient is thriving with no evidence of recurrent or metastatic disease. The final diagnosis was synovial sarcoma confirmed via a SYT gene split performed with fluorescent in situ hybridization (FISH), although the tumor appeared as a low-grade fibrous type in a hematoxylin-eosin section. The first curetted specimen was also confirmed to bear a SYT gene split. Synovial sarcoma has been conventionally recognized as a high-grade sarcoma. Our patient had a tumor that exhibited the characteristics of both a histologically and clinically low-grade tumor. From the present case, we consider that low-grade variants of synovial sarcoma do exist although their existence remains controversial.