ALCOHOL INTAKE AND THE RISK OF CARDIOVASCULAR-DISEASE IN MIDDLE-AGED JAPANESE MEN
ALCOHOL INTAKE AND THE RISK OF CARDIOVASCULAR-DISEASE IN MIDDLE-AGED JAPANESE MEN
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DOI：
10.1161/01.str.26.5.767
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发表时间：
1995-05-01
期刊：
影响因子：
8.3
通讯作者：
KOMACHI, Y
中科院分区：
文献类型：
--
作者：
ISO, H;KITAMURA, A;KOMACHI, Y
背景与目的了解饮酒对中风和其他心血管疾病的影响是一个重要的公共卫生问题。方法对日本三个农村社区的2890名年龄在40~69岁、无中风和冠心病病史的男性进行了为期10年的前瞻性研究。结果共发生中风178例，其中脑出血40例，蛛网膜下腔出血18例，非出血性中风104例，未分类中风16例。饮酒者经年龄调整后患所有中风的风险大约是从不饮酒者的2.5倍；出血性中风的额外风险比非出血性中风更明显。当考虑到高血压类别、血清总胆固醇水平、吸烟和糖尿病时，这些额外风险降低，但在所有中风(2.0；95%可信区间，1.3至3.1)和出血性中风(3.4；95%可信区间，1.2至9.2)中仍然显著。酒精摄入量和非出血性中风的风险之间存在J型关系；饮酒者
Background and Purpose Understanding the effects of alcohol intake on stroke and other cardiovascular diseases is an important issue for public health.Methods A 10.5-year prospective study of the relationship between alcohol intake and cardiovascular disease incidence was conducted in 2890 men, aged 40 to 69 years and free of a history of stroke and coronary heart disease, in three rural communities of Japan.Results One hundred seventy-eight strokes (40 intracerebral hemorrhages, 18 subarachnoid hemorrhages, 104 nonhemorrhagic strokes, and 16 unclassified strokes), 34 coronary heart disease events, and 19 sudden unclassified deaths occurred. Drinkers of greater than or equal to 70 g/d ethanol had an approximately 2.5 times higher age-adjusted risk of all stroke than never-drinkers; the excess risk was more evident for hemorrhagic stroke than nonhemorrhagic stroke. When hypertension category, serum total cholesterol level, cigarette smoking, and diabetes mellitus were taken into account, these excess risks were reduced but remained significant for all stroke (2.0; 95% confidence interval, 1.3 to 3.1) and hemorrhagic stroke (3.4; 95% confidence interval, 1.2 to 9.2). A J-shaped relationship was suggested between alcohol intake and risk of nonhemorrhagic stroke; drinkers of