The structure of the Adh locus of Drosophila mettleri: an intermediate in the evolution of the Adh locus in the repleta group of Drosophila.
The structure of the Adh locus of Drosophila mettleri: an intermediate in the evolution of the Adh locus in the repleta group of Drosophila.
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果蝇 mettleri 的 Adh 基因座的结构：果蝇 repleta 群中 Adh 基因座进化的中间体。
DOI：
10.1093/oxfordjournals.molbev.a040692
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发表时间：
1991
影响因子：
10.7
通讯作者：
Sullivan,DT
中科院分区：
文献类型：
--
作者：
Yum,JS;Starmer,WT;Sullivan,DT
果蝇 repleta 类的 mulleri 和 hydei 亚类的成员具有重复的 Adh 基因。 D. mojavensis、D. mulleri 和 D. hydei 的 Adh 区域包含三个基因：假基因、Adh-2 和 Adh-1，排列在 5' 至 3'。为了了解三重 Adh 结构的进化，我们对 D. mettleri 的 Adh 基因座进行了克隆和测序。该区域由 5' 假基因和 3' 功能性 Adh 基因组成。基于D. mettleri和其他物种的Adh基因的结构和核苷酸序列比较，我们提出祖先Adh基因的初始重复产生了两个串联排列的Adh基因。 more 5' Adh 基因成为假基因，而 more 3' 基因在所有发育阶段仍保持功能。该 3' 基因的第二次重复产生了具有三个基因的 Adh 区域：假基因、Adh-2 和 Adh-1。
Members of species of the mulleri and hydei subgroups of the repleta group of Drosophila have duplicate Adh genes. The Adh regions of D. mojavensis, D. mulleri, and D. hydei contain three genes--a pseudogene, Adh-2, and Adh-1--arranged 5' to 3'. To understand the evolution of the triplicate Adh structure, we have cloned and sequenced the Adh locus of D. mettleri. This region consists of a 5' pseudogene and a 3' functional Adh gene. On the basis of the structure and nucleotide sequence comparisons of Adh genes of D. mettleri and other species, we propose that an initial duplication of the ancestral Adh gene generated two Adh genes arranged in tandem. The more 5' Adh gene became a pseudogene, while the more 3' gene remained functional through all the developmental stages. A second duplication of this 3' gene resulted in Adh regions with three genes--a pseudogene, Adh-2, and Adh-1.