Heat shock genes: regulatory role for differentiation in parasitic protozoa.
Heat shock genes: regulatory role for differentiation in parasitic protozoa.
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热休克基因：寄生原生动物分化的调节作用。
DOI：
10.1126/science.4012301
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Cantor,CR
中科院分区：
文献类型：
--
作者：
VanderPloeg,LH;Giannini,SH;Cantor,CR
寄生性原生动物布氏锥虫和利什曼原虫通过昆虫媒介传播给哺乳动物宿主。宿主之间的温差（25° C和37°C）可能会引起寄生虫的热休克反应。布氏锥虫血流型（锥鞭虫）中热休克基因（与Hsp70和Hsp83同源）的转录物比昆虫（原周期）阶段中的转录物丰富25至100倍。在主要利什曼原虫中，前鞭毛体（昆虫适应）和无鞭毛体（哺乳动物适应）的热休克基因表达模式是不同的。温度变化诱导硕大利什曼原虫前鞭毛体向无鞭毛体分化因此，热休克基因可能是负责这些媒介传播的寄生虫的分化。
The parasitic protozoaTrypanosoma bruceiandLeishmania majorare transmitted by insect vectors to their mammalian hosts. The temperature difference between the hosts (25° and 37°C) may induce a heat shock response in the parasite. Transcripts of heat shock genes (homologous to Hsp70 and Hsp83) were 25 to 100 times more abundant inTrypanosoma bruceibloodstream forms (trypomastigotes) than in insect (procyclic) stages. InLeishmania majorthe patterns of heat shock gene expression in promastigotes (insect-adapted) and amastigotes (mammal-adapted) were different. A temperature shift in vitro induced differentiation ofLeishmania majorfrom promastigotes to amastigotes. Therefore, heat shock genes may be responsible for differentiation of these vector-borne parasites.