Strong resistance of poly (ethylene glycol) based L -tyrosine polyurethanes to protein adsorption and cell adhesion
Strong resistance of poly (ethylene glycol) based L -tyrosine polyurethanes to protein adsorption and cell adhesion
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DOI：
10.1002/pi.3220
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发表时间：
2011-12
影响因子：
3.2
通讯作者：
Jui-Chen Yang;Chao Zhao;I. Hsieh;Senthilram Subramanian;Lingyun Liu;Gang Cheng;Lingyan Li;Stephen Z. D. Cheng;Jie Zheng
中科院分区：
文献类型：
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作者：
Jui-Chen Yang;Chao Zhao;I. Hsieh;Senthilram Subramanian;Lingyun Liu;Gang Cheng;Lingyan Li;Stephen Z. D. Cheng;Jie Zheng
生物污垢涉及蛋白质的吸附、细胞和细菌的黏附以及生物表面和生物实体之间生物膜的形成，是生物医学和工业应用的一个巨大挑战。本文合成了不同相对分子质量的聚乙二醇型L酪氨酸型聚氨酯(L聚氨酯)，对其进行了表征，并用旋涂法在金表面进行了涂覆。通过蛋白质吸附和细胞粘附性评价了不同的L-聚氨酯膜的无污染活性。表面等离子体共振和细胞分析结果表明，这些L-聚氨酯中的聚乙二醇组分具有优异的抗蛋白质吸附和细胞附着性能。这项工作为血液接触设备的潜在应用提供了替代和有效的生物材料。版权所有(C)2011化学工业学会
Biofouling that involves protein adsorption, cell and bacteria adhesion, and biofilm formation between a surface and biological entities is a great challenge for biomedical and industry applications. In this work, L-tyrosine-derived polyurethanes (L-polyurethane) with different molecular weights of poly(ethylene glycol) (PEG) were synthesized, characterized and coated on gold surfaces using spin-coating. The non-fouling activity of different L-polyurethane films was evaluated by protein adsorption and cell adhesion. Surface plasmon resonance and cell assay results demonstrate that the PEG content in these L-polyurethanes contributes excellent resistance to protein adsorption and cell attachments. This work provides alternative and effective biomaterials for potential applications in blood-contacting devices. Copyright © 2011 Society of Chemical Industry