Hormonal regulation of extrathymic gut T cell development: involvement of thyroid stimulating hormone.
Hormonal regulation of extrathymic gut T cell development: involvement of thyroid stimulating hormone.
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DOI：
10.1006/cimm.1995.1040
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发表时间：
1995-04
影响因子：
4.3
通讯作者：
J. Wang;J. Klein
中科院分区：
文献类型：
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作者：
J. Wang;J. Klein
我们最近证明，缺乏被认为是胸腺依赖性（TD）T细胞的上皮内淋巴细胞（IEL）的无胸腺小鼠在用下丘脑衍生的神经肽促甲状腺激素释放激素（TRH）进行外源治疗后会发育出这些细胞。为了探讨神经内分泌 (NE) 激素影响 IEL 发育的机制，我们研究了促甲状腺激素 (TSH)（一种受 TRH 调节的垂体激素）对新生胸腺切除 (NTX) 成年小鼠 IEL 发育的影响。用外源性 TSH 治疗 3 周的成年 NTX 小鼠以与 TRH 治疗的 NTX 小鼠类似的方式形成正常比例和数量的 TD（TCR αβ+、CD8 αβ+、CD5+ 和 Thy-1+）IEL。激素治疗的效果是持久的，因为在 TSH 治疗期间形成的 IEL 亚群在 TSH 体内已知寿命之后很长时间才出现，并且因为 IEL 的数量仍然高于未治疗的小鼠。这些发现表明，TD IEL 通过一系列免疫和激素相互作用在胸腺外发育，这些相互作用在胚胎生命的某个阶段受到胸腺的调节。
We recently demonstrated that athymic mice which lack intraepithelial lymphocytes (IELs) considered to be thymus-dependent (TD) T cells develop those cells following exogenous treatment with the hypothalamic-derived neuropeptide, thyrotropin-releasing hormone (TRH). To explore the mechanism by which neuroendocrine (NE) hormones influence the development of IELs, we have studied the effects of thyroid-stimulating hormone (TSH), a pituitary hormone that is regulated by TRH, on IEL development in adult mice that were neonatally thymectomized (NTX). Adult NTX mice treated with exogenous TSH for 3 weeks developed normal proportions and numbers of TD (TCR alpha beta+, CD8 alpha beta+, CD5+, and Thy-1+) IELs in a manner similar to that of TRH-treated NTX mice. The effect of hormone therapy was long-lasting in that IEL subsets which developed during TSH treatment were present well after the known lifespan of TSH in vivo, and because the numbers of IEL remained higher than in untreated mice. These findings suggest that TD IELs develop extrathymically through a series of immunologic and hormonal interactions which are regulated by the thymus during some phase of embryonic life.