Pol X DNA polymerases contribute to NHEJ flexibility.

Pol X DNA polymerases contribute to NHEJ flexibility.
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DOI:
10.1038/s41594-022-00904-6
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发表时间:
2023-01
影响因子:
16.8
通讯作者:
Lieber, Michael R.
Lieber, Michael R.
中科院分区:
生物学1区
文献类型:
--
作者:
Lieber, Michael R.

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关于DNA聚合酶λ的新工作突出了它非凡的灵活性。这符合DNA修复过程的一般适应性,其中涉及这种酶-非同源末端连接-这允许这种机制处理不同类型的断裂DNA末端,以恢复双链体结构,尽管在连接处丢失信息。
New work on DNA polymerase λ highlights its remarkable flexibility. This fits with the generally adaptable nature of the DNA-repair process in which this enzyme is involved — nonhomologous end-joining — which allows this mechanism to handle diverse types of broken DNA ends in order to restore the duplex structure, albeit with a loss of information at the join.
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