The high mobility group A1 gene: transforming inflammatory signals into cancer?
The high mobility group A1 gene: transforming inflammatory signals into cancer?
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DOI：
10.1158/0008-5472.can-09-1212
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发表时间：
2010-01-15
期刊：
影响因子：
11.2
通讯作者：
Resar LM
中科院分区：
文献类型：
--
作者：
Resar LM
HMGA1在胚胎发育过程中和低分化肿瘤中高表达，在某些肿瘤中高水平预示着预后不良。HMGA1在培养细胞中诱导致癌转化，并在转基因小鼠中引起侵袭性癌症，而阻断HMGA1则干扰实验模型中的转化。这些发现表明HMGA1在癌症中起着关键作用。这篇综述主要集中在最近描述的两个HMGA1转录靶点，它们介导炎症信号并驱动恶性转化，因为它们可以作为生物标记物或治疗靶点。进一步阐明HMGA1在转化中的功能有望对我们的抗癌战争产生重大影响。
HMGA1 is highly expressed during embryogenesis and in poorly differentiated cancers, and high levels portend a poor prognosis in some tumors. HMGA1 induces oncogenic transformation in cultured cells and causes aggressive cancers in transgenic mice, while blocking it interferes with transformation in experimental models. These findings suggest a pivotal role for HMGA1 in cancer. This review focuses on two recently described HMGA1 transcriptional targets that mediate inflammatory signals and drive malignant transformation because they could serve as biomarkers or therapeutic targets. Further elucidation of HMGA1 function in transformation promises to have a major impact on our war on cancer.