Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction
Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction
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DOI：
10.1016/j.actbio.2010.03.024
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发表时间：
2010-09-01
影响因子：
9.7
通讯作者：
Van Meerbeek, Bart
中科院分区：
文献类型：
--
作者：
Yoshihara, Kumiko;Yoshida, Yasuhiro;Van Meerbeek, Bart
虽然利用粘接剂技术可以微创、几乎不可见地重建牙体，但复合牙体修复的临床寿命仍然很短。吸水被认为是生物材料-牙齿结合不稳定的主要原因。然而，界面降解的实际机制尚不清楚。在这里，我们报告了纳米控制的生物材料-硬组织界面上的分子相互作用如何提高键的耐久性。使用对羟基磷灰石中的钙具有强化学亲和力的功能单体对于长期耐久性至关重要。相关的x射线衍射和固态核磁共振揭示了在界面上的分子相互作用，单体与羟基磷灰石形成稳定的离子键，与不稳定的磷酸钙盐的沉积在时间上竞争。先进的牙齿-生物材料相互作用模型不仅可以深入了解键降解的机制，而且为开发更耐用的牙齿重建功能单体提供了基础。(C) 2010材料学报Elsevier Ltd.出版。版权所有。
Although decayed/fractured teeth can be reconstructed minimally invasively and nearly invisibly using adhesive technology, the clinical longevity of dental composite restorations is still too short. Water sorption is thought to be the principal cause of destabilization of the biomaterial-tooth bond. However, the actual mechanisms of interfacial degradation are far from understood. Here we report how nano-controlled molecular interaction at the biomaterial-hard tissue interface can improve bond durability. The use of functional monomers with a strong chemical affinity for the calcium in hydroxyapatite is essential for long-term durability. Correlative X-ray diffraction and solid-state nuclear magnetic resonance disclosed a time-dependent molecular interaction at the interface with stable ionic bond formation of the monomer to hydroxyapatite competing in time with the deposition of less stable calcium phosphate salts. The advanced tooth-biomaterial interaction model gives not only an insight into the mechanisms of bond degradation, but also provides a basis to develop functional monomers for more durable tooth reconstruction. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.