I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People.
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People.
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我的衰老和炎症：老年人严重Covid-19的危险因素。
DOI：
10.3389/fimmu.2020.579220
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发表时间：
2020
影响因子：
7.3
通讯作者：
Sato MN
中科院分区：
文献类型：
--
作者：
Pietrobon AJ;Teixeira FME;Sato MN
老年人更容易受到各种感染，因为在衰老过程中发生的免疫变化。这些变化统称为“免疫衰老”，除了炎性细胞因子的产生加剧之外，还包括先天性和适应性免疫应答的减少。这种免疫功能障碍的情况及其与老年人疾病发展的关系已得到广泛研究，特别是在可能致命的感染中，如流感和最近的COVID-19。在目前的SARS-CoV-2感染情况下，已经提出了许多老年人疾病发病机制。为了更好地了解COVID-19在这一群体中的动态，必须很好地阐明与免疫衰老相关的方面。在这篇文章中，我们讨论了参与免疫衰老的主要机制，以及它们与高龄个体对SARS-CoV-2感染的易感性和更严重的疾病状况的可能相关性。
Old individuals are more susceptible to various infections due to immunological changes that occur during the aging process. These changes named collectively as “immunosenescence” include decreases in both the innate and adaptive immune responses in addition to the exacerbated production of inflammatory cytokines. This scenario of immunological dysfunction and its relationship with disease development in older people has been widely studied, especially in infections that can be fatal, such as influenza and, more recently, COVID-19. In the current scenario of SARS-CoV-2 infection, many mechanisms of disease pathogenesis in old individuals have been proposed. To better understand the dynamics of COVID-19 in this group, aspects related to immunological senescence must be well elucidated. In this article, we discuss the main mechanisms involved in immunosenescence and their possible correlations with the susceptibility of individuals of advanced age to SARS-CoV-2 infection and the more severe conditions of the disease.