The balance between feeling and knowing: affective and cognitive empathy are reflected in the brain's intrinsic functional dynamics
The balance between feeling and knowing: affective and cognitive empathy are reflected in the brain's intrinsic functional dynamics
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DOI：
10.1093/scan/nsr051
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发表时间：
2012-08-01
影响因子：
4.2
通讯作者：
Kelly, Clare
中科院分区：
文献类型：
--
作者：
Cox, Christine L.;Uddin, Lucina Q.;Kelly, Clare
情感移情（AE）在临床和神经上与认知移情（CE）不同。虽然AE在精神病中被选择性地破坏，但自闭症与CE缺陷相关。尽管存在这种分离，但AE和CE共同促成了正常的人类共情体验。AE“相对于”CE的个体差异的维度测量捕获了这种相互作用，并且可以揭示超出AE和CE单独检测的脑行为关系。使用静息态功能磁共振成像和措施的同情心在健康的成年人，我们表明，相对移情能力（REA）反映在大脑的内在功能动力学。AE的优势与社交情感区域（腹前额叶、眶额皮质、杏仁核、膝周前扣带回）之间更强的功能连接相关。CE的优势与涉及内感受、自主监测和社会认知处理的区域（脑干、上级颞沟、腹前沟）之间的连接性更强有关。这些模式与AE和CE分别观察到的模式不同。最后，REA和几个功能连接的强度与精神病理学症状相关。这些研究结果表明，REA提供了一个维度指数的移情功能和病理倾向的健康成人，这是反映在与社会和情绪认知相关的神经系统的内在功能动力学。
Affective empathy (AE) is distinguished clinically and neurally from cognitive empathy (CE). While AE is selectively disrupted in psychopathy, autism is associated with deficits in CE. Despite such dissociations, AE and CE together contribute to normal human empathic experience. A dimensional measure of individual differences in AE 'relative to' CE captures this interaction and may reveal brain-behavior relationships beyond those detectable with AE and CE separately. Using resting-state fMRI and measures of empathy in healthy adults, we show that relative empathic ability (REA) is reflected in the brain's intrinsic functional dynamics. Dominance of AE was associated with stronger functional connectivity among social-emotional regions (ventral anterior insula, orbitofrontal cortex, amygdala, perigenual anterior cingulate). Dominance of CE was related to stronger connectivity among areas implicated in interoception, autonomic monitoring and social-cognitive processing (brainstem, superior temporal sulcus, ventral anterior insula). These patterns were distinct from those observed with AE and CE separately. Finally, REA and the strength of several functional connections were associated with symptoms of psychopathology. These findings suggest that REA provides a dimensional index of empathic function and pathological tendencies in healthy adults, which are reflected in the intrinsic functional dynamics of neural systems associated with social and emotional cognition.