Signal transduction through the T cell receptor is dynamically regulated by balancing kinase and phosphatase activities.
Signal transduction through the T cell receptor is dynamically regulated by balancing kinase and phosphatase activities.
复制标题
通过 T 细胞受体的信号转导通过平衡激酶和磷酸酶活性进行动态调节。
DOI：
10.1016/s0006-291x(02)00925-7
复制
发表时间：
2002
影响因子：
3.1
通讯作者：
Levine,AlanD
中科院分区：
文献类型：
--
作者：
Schade,AndrewE;Levine,AlanD
在 T 细胞受体参与的几秒钟内，一系列特征明确的酪氨酸磷酸化事件介导细胞激活。人们普遍认为，这些初始磷酸化保持稳定，直到蛋白质酪氨酸磷酸酶将细胞恢复到基础水平。基于可以调节磷酸化动力学的外周血 T 细胞激活模型，我们提出了另一种假设，即 T 细胞信号传导是高度动态的。我们的结果表明，酪氨酸磷酸化和去磷酸化在 T 细胞受体交联后同时发生，并受到激酶和磷酸酶的微妙平衡调节。
Within seconds of T cell receptor engagement, a well-characterized series of tyrosine phosphorylation events mediate cellular activation. It is widely accepted that these initial phosphorylations remain stable until protein tyrosine phosphatases return the cell to its basal level. Based on a model of peripheral blood T cell activation, in which the kinetics of phosphorylation can be modulated, we propose an alternate hypothesis that T cell signaling is highly dynamic. Our results demonstrate that tyrosine phosphorylation and dephosphorylation are occurring co-temporally after T cell receptor cross-linking, regulated by a delicate balance of kinases and phosphatases.