Differential Scanning Calorimetry (DSC): A tool to study the thermal behavior of lipid bilayers and liposomal stability
Differential Scanning Calorimetry (DSC): A tool to study the thermal behavior of lipid bilayers and liposomal stability
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DOI：
10.1080/08982100802310261
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Demetzos, Costas
中科院分区：
文献类型：
--
作者：
Demetzos, Costas
利用热力学技术测定辅料药用化合物的热应力及其在配制过程中的相互作用，利用热分析技术测量药物的物理化学性质和稳定性随温度或时间的变化。差示扫描量热法(DSC)是一种适用于制药工业中测定样品纯度、晶型和熔点的热分析技术。它也被认为是一种通过测量影响脂质体混悬液在给定储存条件下稳定性的热力学参数(即Delta H和Tm)来研究脂双层和脂类药物递送系统的热行为的工具。
Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process.The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using thermal analysis.Differential Scanning Calorimetry (DSC) is a suitable thermal analysis technique for determining the purity, the polymorphic forms and the melting point of a sample in the Pharmaceutical Industry. It is also considered as a tool to study the thermal behavior of lipid bilayers and of lipidic drug delivery systems, like liposomes by measuring thermodynamic parameters (i.e. Delta H and Tm), which affect the stability of the liposomal suspension under given storage conditions.