Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension
Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension
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DOI：
10.1161/01.hyp.0000132767.74476.64
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发表时间：
2004-07-01
期刊：
影响因子：
8.3
通讯作者：
Seals, DR
中科院分区：
文献类型：
--
作者：
Gates, PE;Tanaka, H;Seals, DR
我们在12名未经治疗的老年（64 +/- 2岁）男性和女性（各6名）1期收缩期高血压患者中测定了饮食钠限制对大弹性动脉顺应性和收缩压（SBP）的时间效应。基线测量后，受试者被分配到4周的低钠或正常钠摄入（随机，交叉设计）。限钠治疗第1周结束时，尿钠排泄量（54 ± 11 mmol/d，P < 0.01）较基线（135 ± 14）减少60%。与基线值（0.11 ± 0.01 mm/mm Hg）相比，限钠第1周结束时颈动脉顺应性增加了27%（至0.14 ± 0.02，P < 0.05），第2周达到峰值（+46%，至0.16 ± 0.02，P < 0.01）。同样，仰卧位静息肱动脉收缩压在限钠治疗第1周降低>5 mm Hg，第2周达到峰值（-12 mm Hg，P
We determined the temporal effects of dietary sodium restriction on large elastic artery compliance and systolic blood pressure (SBP) in 12 untreated, older ( 64 +/- 2 years) men and women ( 6 each) with stage 1 systolic hypertension. After baseline measurements subjects were assigned to 4 weeks of low or normal sodium intake ( randomized, crossover design). Urinary sodium excretion was reduced by 60% by the end of week 1 of sodium restriction ( 54 +/- 11 mmol/d, P < 0.01) versus baseline ( 135 +/- 14). Compared with baseline (0.11 +/- 0.01 mm/mm Hg), carotid artery compliance was increased by 27% (to 0.14 +/- 0.02, P < 0.05) at the end of week 1 of sodium restriction, attaining peak levels by week 2 (+46%, to 0.16 +/- 0.02, P < 0.01). Similarly, supine resting brachial artery SBP was reduced by >5 mm Hg by week 1 of sodium restriction, attaining peak reductions by week 2 (-12 mm Hg, P