Risk factors for progression of chronic kidney disease.
Risk factors for progression of chronic kidney disease.
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DOI：
10.1097/mop.0b013e328336ebb0
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发表时间：
2010-04
影响因子：
3.6
通讯作者：
Wong C
中科院分区：
文献类型：
--
作者：
Staples A;Wong C
概述了慢性肾脏病（CKD）进展的已确定风险因素，重点关注儿科人群。在过去的十年里，我们对终末期前肾衰竭的理解和研究发生了重大变化。肾小球滤过率（GFR）测量和GFR估计方程的最新改进是识别和关联儿童CKD进展风险因素的重要工具。在儿童CKD中，就诊时肾功能水平较低、蛋白尿水平较高和高血压是GFR下降更快的已知标志物。前基因组时代报道的贫血和其他风险因素需要进一步研究和验证。全基因组关联研究已经确定了为CKD进展提供新的遗传风险因素的遗传位点。随着CKD儿童的队列研究逐渐成熟，他们开始对CKD进展的评估进行重要的改进。虽然许多传统的肾脏进展风险因素肯定会被评估，但这些队列对于评估全基因组研究确定的新风险因素将非常重要。
Provides an overview of the identified risk factors for chronic kidney disease (CKD) progression emphasizing the pediatric population. Over the past ten years, there have been significant changes to our understanding and study of pre-terminal kidney failure. Recent refinements in the measurement of glomerular filtration rate (GFR) and GFR estimating equations are important tools for identification and association of risk factors for CKD progression in children. In pediatric CKD, lower level of kidney function at presentation, higher levels of proteinuria, and hypertension are known markers for a more rapid decline in GFR. Anemia and other reported risk factors from the pre-genomic era have need for further study and validation. Genome-wide association studies have identified genetic loci which have provided novel genetic risk factors for CKD progression. With cohort studies of children with CKD becoming mature, they have started to yield important refinements to the assessment of CKD progression. While many of the traditional risk factors for renal progression will certainly be assessed, such cohorts will be important for evaluating novel risk factors identified by genome-wide studies.