Improving the human hazard characterization of chemicals: a Tox21 update.
Improving the human hazard characterization of chemicals: a Tox21 update.
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DOI：
10.1289/ehp.1205784
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发表时间：
2013-07
影响因子：
10.4
通讯作者：
Bucher JR
中科院分区：
文献类型：
--
作者：
Tice RR;Austin CP;Kavlock RJ;Bucher JR
背景资料：2008年，美国国家环境健康科学研究所/国家毒理学计划，美国环境保护署的国家计算毒理学中心和国家人类基因组研究所/国家卫生研究院化学基因组学中心达成了一项关于“高通量筛选，毒性途径分析和结果的生物学解释”的协议。2010年，美国食品和药物管理局（FDA）加入了这项合作，非正式地称为Tox 21。目的：Tox 21伙伴商定制定一个愿景并制定一项实施战略，将化学品危害评估从传统的实验动物毒理学研究转向基于目标特异性、基于机制的生物学观察，主要是通过体外分析获得的。讨论内容：在此，我们概述了Tox 21合作伙伴在FDA加入合作之前所做的努力，描述了为开发目前正在使用的科学和技术所采取的方法，评估了目前的状况，并确定了可能阻碍进一步进展的问题，并提出了解决这些问题的方法。结论：Tox 21面临着一些非常困难的问题。然而，我们正在将来自不同技术和终点的数据整合到有效的毒理学系统生物学方法中。只有在获得广泛的化学和生物/毒理学领域的全面知识时才能做到这一点。迄今为止的努力反映了一个极其复杂的计划的初始阶段，这个计划可能需要几十年才能完全实现其目标。然而，即使在这个阶段，所获得的信息已经引起了国际科学界的关注，我们相信这些努力预示了毒理学的未来。
Background: In 2008, the National Institute of Environmental Health Sciences/National Toxicology Program, the U.S. Environmental Protection Agency’s National Center for Computational Toxicology, and the National Human Genome Research Institute/National Institutes of Health Chemical Genomics Center entered into an agreement on “high throughput screening, toxicity pathway profiling, and biological interpretation of findings.” In 2010, the U.S. Food and Drug Administration (FDA) joined the collaboration, known informally as Tox21. Objectives: The Tox21 partners agreed to develop a vision and devise an implementation strategy to shift the assessment of chemical hazards away from traditional experimental animal toxicology studies to one based on target-specific, mechanism-based, biological observations largely obtained using in vitro assays. Discussion: Here we outline the efforts of the Tox21 partners up to the time the FDA joined the collaboration, describe the approaches taken to develop the science and technologies that are currently being used, assess the current status, and identify problems that could impede further progress as well as suggest approaches to address those problems. Conclusion: Tox21 faces some very difficult issues. However, we are making progress in integrating data from diverse technologies and end points into what is effectively a systems-biology approach to toxicology. This can be accomplished only when comprehensive knowledge is obtained with broad coverage of chemical and biological/toxicological space. The efforts thus far reflect the initial stage of an exceedingly complicated program, one that will likely take decades to fully achieve its goals. However, even at this stage, the information obtained has attracted the attention of the international scientific community, and we believe these efforts foretell the future of toxicology.
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影响因子：
5.6
作者：
Judson RS;Martin MT;Egeghy P;Gangwal S;Reif DM;Kothiya P;Wolf M;Cathey T;Transue T;Smith D;Vail J;Frame A;Mosher S;Hubal EAC;Richard AM
通讯作者：
Richard AM
影响因子：
--
作者：
Houck, Keith A.;Dix, David J.;Berg, Ellen L.
通讯作者：
Berg, Ellen L.
影响因子：
4.1
作者：
Huang, Ruili;Southall, Noel;Austin, Christopher P.
通讯作者：
Austin, Christopher P.
影响因子：
3.6
作者：
Martin, Matthew T.;Knudsen, Thomas B.;Dix, David J.
通讯作者：
Dix, David J.
影响因子：
10.4
作者：
Huang R;Xia M;Cho MH;Sakamuru S;Shinn P;Houck KA;Dix DJ;Judson RS;Witt KL;Kavlock RJ;Tice RR;Austin CP
通讯作者：
Austin CP