High Visfatin Expression in Breast Cancer Tissue Is Associated with Poor Survival
High Visfatin Expression in Breast Cancer Tissue Is Associated with Poor Survival
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DOI：
10.1158/1055-9965.epi-11-0399
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发表时间：
2011-09-01
影响因子：
3.8
通讯作者：
Yuan, Shyng-Shiou F.
中科院分区：
文献类型：
--
作者：
Lee, Yi-Chen;Yang, Yi-Hsin;Yuan, Shyng-Shiou F.
背景：脂肪细胞因子（脂肪细胞分泌的激素）在乳腺癌的发展中发挥着关键作用。测定乳腺癌组织中内脂素（一种新发现的脂肪细胞因子）的表达，并将其与患者的临床病理变量相关。方法：通过免疫组织化学分析乳腺癌组织中内脂素的表达。使用chi(2)检验，Visfatin表达与临床病理变量以及复发率相关。通过Kaplan-Meier估计评估内脂素对无病生存和总生存的预后价值，并通过对数秩检验评估曲线之间差异的显着性。结果：乳腺癌组织中内脂素的高表达与肿瘤大小、雌激素受体（ER）阴性和孕激素受体（PR）阴性显着相关。激素治疗（而非放疗或化疗）降低了内脂素高表达患者的复发率。虽然内脂素高表达单独与较差的无病生存率和总生存率相关，但当内脂素高表达与 ER 和 PR 阴性状态相结合时，观察到更差的无病生存率和总生存率。 Cox回归分析还显示，Visfatin是无病生存和总生存的独立预测因子。结论：乳腺癌组织中Visfatin的高表达与更恶性的癌症行为以及较差的患者生存率相关。影响：Visfatin是乳腺癌的独立预后预测因子。癌症流行病学生物标志物20（9）； 1892-901。 (C)2011 AACR。
Background: Adipocytokines, adipocyte-secreted hormones, play a critical role in breast cancer development. The expression of visfatin, a newly discovered adipocytokine, in breast cancer tissues was determined and correlated with patient clinicopathologic variables.Methods: Visfatin expression in breast cancer tissues was analyzed by immunohistochemistry. Visfatin expression was correlated with clinicopathologic variables as well as recurrence rates, using the chi(2) test. The prognostic value of visfatin for disease-free and overall survival was evaluated by Kaplan-Meier estimates, and the significance of differences between curves was evaluated by the log-rank test.Results: High visfatin expression in breast cancer tissues was significantly correlated with tumor size, estrogen receptor (ER) negativity, and progesterone receptor (PR) negativity. Hormone therapy, but not radiotherapy or chemotherapy, decreased the recurrence rate in patients with high visfatin expression. Whereas high visfatin expression alone was associated with poor disease-free and overall survival, worse disease-free and overall survival was observed when high visfatin expression was combined with ER- and PR-negative status. Cox regression analysis also revealed that visfatin is an independent predictor of disease-free and overall survival.Conclusion: High visfatin expression in breast cancer tissue is associated with more malignant cancer behavior as well as poor patient survival.Impact: Visfatin is an independent prognosis predictor for breast cancer. Cancer Epidemiol Biomarkers Prev; 20(9); 1892-901. (C)2011 AACR.