Does programmed CTL proliferation optimize virus control?
Does programmed CTL proliferation optimize virus control?
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DOI：
10.1016/j.it.2005.04.007
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发表时间：
2005-06-01
影响因子：
16.8
通讯作者：
Thomsen, AR
中科院分区：
文献类型：
--
作者：
Wodarz, D;Thomsen, AR
CD8 T细胞或细胞毒性T淋巴细胞应答通过抗原非依赖性增殖和分化程序发展。这与之前的想法相反，之前的想法是需要连续的抗原刺激。本意见讨论了为什么大自然选择了增殖计划，以及它如何与持续刺激相比较。虽然这两种机制在慢性感染期间不应导致显著不同的动力学，但它们确实在急性感染中产生差异。我们认为，程序性增殖是更好的清除，而连续刺激是更好地限制急性症状。在体内观察到的7 - 10次程序化细胞分裂可能是这种权衡的优化。我们还讨论了在何种情况下，该计划不需要或不需要CD4 T细胞帮助清除。
CD8 T-cell or cytotoxic T-lymphocyte responses develop through an antigen-independent proliferation and differentiation program. This is in contrast to the previous thinking, which was that continuous antigenic stimulation was required. This Opinion discusses why nature has chosen the proliferation program and how it compares to continuous stimulation. Although the two mechanisms should not lead to significantly different dynamics during chronic infection, they do make a difference in acute infection. We argue that programmed proliferation is better at clearance, whereas continuous stimulation is better at limiting acute symptoms. The 7-10 programmed cell divisions observed in vivo might be an optimization of this trade-off. We also discuss the conditions under which the program does or does not require CD4 T-cell help for clearance.