Grabbing amphiregulin by the tail to better understand keratinocyte growth.
Grabbing amphiregulin by the tail to better understand keratinocyte growth.
复制标题
抓住双调蛋白的尾巴以更好地了解角质形成细胞的生长。
DOI：
10.1038/jid.2010.199
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Seykora,JohnT
中科院分区：
文献类型：
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作者：
Seykora,JohnT
两性调节蛋白(AREG)是角质形成细胞、癌症和包括银屑病在内的增生性表皮疾病中细胞生长的重要调节因子。Stoll和他的同事提出的数据表明，双调节蛋白的细胞质羧基末端结构域通过表皮生长因子受体在调节自分泌角质形成细胞生长方面发挥重要作用。这些观察结果提出了关于AREG细胞质C-末端区域功能的新的和有趣的生物学问题。
Amphiregulin (AREG) is an important regulator of cellular growth in keratinocytes, carcinomas, and hyperproliferative epidermal disorders, including psoriasis. Stoll and colleagues present data suggesting that the cytoplasmic carboxy-terminal domain of amphiregulin plays an important role in regulating autocrine keratinocyte growth through the epidermal growth factor receptor. These observations raise novel and interesting biological questions regarding the function of the cytoplasmic C-terminal region of AREG.