Modelling mitral valvular dynamics-current trend and future directions.
Modelling mitral valvular dynamics-current trend and future directions.
复制标题
二尖瓣动力学建模 - 当前趋势和未来方向。
DOI：
10.1002/cnm.2858
复制
发表时间：
2017-10
影响因子：
2.1
通讯作者：
Luo X
中科院分区：
文献类型：
--
作者：
Gao H;Qi N;Feng L;Ma X;Danton M;Berry C;Luo X
二尖瓣功能障碍导致发病率和过早死亡率，并且仍然是世界范围内的主要医学问题。计算建模旨在了解人类二尖瓣的生物力学，并可能导致二尖瓣疾病的新治疗，预防和诊断的发展。与主动脉瓣相比，二尖瓣由于其高度复杂的结构以及与血流和心室的强烈相互作用而受到的研究要少得多。然而，对二尖瓣建模的兴趣正在增长，并且随着计算技术和成像工具的先进发展，复杂程度正在增加。本综述总结了二尖瓣的最新建模技术，包括静态和动态模型、具有流体-结构相互作用的模型以及具有左心室相互作用的模型。还讨论了挑战和未来的方向。
Dysfunction of mitral valve causes morbidity and premature mortality and remains a leading medical problem worldwide. Computational modelling aims to understand the biomechanics of human mitral valve and could lead to the development of new treatment, prevention and diagnosis of mitral valve diseases. Compared with the aortic valve, the mitral valve has been much less studied owing to its highly complex structure and strong interaction with the blood flow and the ventricles. However, the interest in mitral valve modelling is growing, and the sophistication level is increasing with the advanced development of computational technology and imaging tools. This review summarises the state‐of‐the‐art modelling of the mitral valve, including static and dynamics models, models with fluid‐structure interaction, and models with the left ventricle interaction. Challenges and future directions are also discussed.