CARDIOVASCULAR CHANGES BY LONG-TERM INHIBITION OF THE RENIN-ANGIOTENSIN SYSTEM IN AGING
CARDIOVASCULAR CHANGES BY LONG-TERM INHIBITION OF THE RENIN-ANGIOTENSIN SYSTEM IN AGING
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DOI：
10.1161/01.hyp.25.3.437
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发表时间：
1995-03-01
期刊：
影响因子：
8.3
通讯作者：
FERDER, L
中科院分区：
文献类型：
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作者：
INSERRA, F;ROMANO, L;FERDER, L
我们对四组 20 只雌性小鼠进行了研究，以评估血管紧张素转换酶在自然衰老过程中对心肌和血管的长期影响。三组从断奶到24月龄期间在水中接受依那普利（A组，20mg/L；B组，10mg/L；C组，5mg/L）； D组作为对照。 24 个月后存活的动物被处死，并进行形态测量研究。接受依那普利的动物的总体重较高。治疗组的心脏重量相对于总体重低于对照组。心脏形态测量研究显示，接受血管紧张素转换酶抑制剂的动物心肌硬化程度较低（A 组至 D 组分别为 0.9+/-0.6%、1.1+/-0.2%、1.03+/-0.1% 和 9.5+/-4.3%；P
We studied four groups of 20 female mice to evaluate the long-term effect of an angiotensin-converting enzyme on myocardium and vessels during the natural process of aging. Three groups received enalapril in water from weaning to 24 months of age (group A, 20 mg/L; group B, 10 mg/L; group C, 5 mg/L); group D served as a control. Animals surviving after 24 months were killed, and morphometric studies were performed. Total corporal weight was higher in animals receiving enalapril. Cardiac weight relative to total body weight was lower in the treated groups than in the control group. Cardiac morphometric studies showed lower myocardiosclerosis in animals receiving angiotensin-converting enzyme inhibitor (groups A through D, respectively, 0.9+/-0.6%, 1.1+/-0.2%, 1.03+/-0.1%, and 9.5+/-4.3%; P