Statistical analysis of Japanese thorotrast-administered autopsy cases.
Statistical analysis of Japanese thorotrast-administered autopsy cases.
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日本胸腔穿刺术尸检病例的统计分析。
DOI：
10.1016/0013-9351(79)90157-9
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发表时间：
1979
影响因子：
8.3
通讯作者：
S. Watanabe
中科院分区：
文献类型：
--
作者：
T. Mori;Y. Kato;T. Shimamine;S. Watanabe
将1945-1975年期间144例日本尸检病例的死亡原因与1958-1973年期间日本病理尸检病例年鉴中记录的相同年龄段的未使用Thorotrast的尸检病例进行了比较。该比较显示，Thorotrast给药病例中恶性肝脏肿瘤的发生率高出10倍以上。增加的原因是肝血管内皮瘤和胆管癌的发病率增加。Thorotrast组中发现的肝硬化唯一显著增加发生在女性病例中。发现一些Thorotrast给药病例发生了髓性白血病和红白血病。Thorotrast组中再生障碍性贫血的病例数也显著增加，但在临床和病理学上这些都是不典型的。未观察到淋巴性白血病。Thorotrast组和对照组的恶性淋巴瘤或骨肉瘤发生率无显著差异。另一方面，对照组中肺癌的发生率显著高于Thorotrast给药组。
The causes of death of 144 Japanese autopsy cases during 1945–1975, who had been intravascularly injected with Thorotrast in life, were compared with those of non-Thorotrast-administered autopsy cases in the same age bracket, recorded in the Annals of Japanese Pathological Autopsy Cases during 1958–1973. This comparison revealed that the incidence of malignant hepatic tumors was more than 10 times higher in the Thorotrast-administered cases. The increase was attributable to an increased incidence of hemangioen-dothelioma and cholangiocarcinoma of the liver. The only significant increase of liver cirrhosis found to exist in the Thorotrast group occurred in the female cases. Some of the Thorotrast-administered cases were found to have developed myeloid leukemia and erythroleukemia. There was also a significant increase in the number of cases of aplastic anemia in the Thorotrast group, but clinically and pathologically these were atypical. Lymphatic leukemia was not observed. No significant difference was found in the incidence of either malignant lymphomas or osteosarcomas in the Thorotrast group and the controls. Lung cancer, on the other hand, showed a significantly higher incidence among the controls than among the Thorotrast-administered cases.