Do interictal spikes sustain seizures and epileptogenesis?
Do interictal spikes sustain seizures and epileptogenesis?
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DOI：
10.1111/j.1535-7511.2006.00146.x
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发表时间：
2006-11-01
影响因子：
3.6
通讯作者：
de Curtis, M
中科院分区：
文献类型：
--
作者：
Avoli, Massimo;Biagini, Giuseppe;de Curtis, M
癫痫患者两次发作之间的脑电图可观察到发作间期尖峰。迄今为止，发作间期事件在癫痫发作和癫痫发生中所起的作用仍然难以捉摸。虽然发作间期尖峰可能预示着电图癫痫发作的发生，但实验数据表明海马驱动的发作间期事件可以防止癫痫发作沉淀。与发作间期事件在癫痫发作中的作用相比，更不清楚的是发作间期尖峰是否以及如何促进癫痫发生。因此，虽然边缘神经元网络内的可塑性变化可能是由持续的发作间期活动引起的，但实验证据支持这样的观点：癫痫发生伴随着海马驱动的发作间期活动的减少。
Interictal spiking is seen in the EEG of epileptic patients between seizures. To date, the roles played by interictal events in seizure occurrence and in epileptogenesis remain elusive. While interictal spikes may herald the onset of electrographic seizures, experimental data indicate that hippocampus-driven interictal events prevent seizure precipitation. Even less clear than the role of interictal events in seizure occurrence is whether and how interictal spikes contribute to epileptogenesis. Thus, while plastic changes within limbic neuronal networks may result from ongoing interictal activity, experimental evidence supports the view that epileptogenesis is accompanied by a decrease in hippocampus-driven interictal activity.