Establishing an Imaging Protocol for Detection of Vascularity within the Median Nerve Using Contrast-Enhanced Ultrasound.
Establishing an Imaging Protocol for Detection of Vascularity within the Median Nerve Using Contrast-Enhanced Ultrasound.
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DOI：
10.1177/8756479313503211
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Sommerich CM
中科院分区：
文献类型：
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作者：
Evans KD;Volz KR;Roll SC;Hutmire CM;Pargeon RL;Buford JA;Sommerich CM
本临床前研究旨在开发离散的超声仪器设置和安全的造影剂剂量，以始终显示沿着正中神经的神经周血管分布。这组成像研究使用年轻成年雌性猴（Macaca fascicularis）的便利队列进行。超声设备设置和剂量在整个成像系列中进行了改进，以确保一致的对比增强超声成像。机械指数0.13始终用于成像。在5分钟内引入0.04 mL去甲肾上腺素/0.96 mL生理盐水的混悬液，总剂量为0.8 mL造影剂溶液，对神经周血管进行成像。高剂量和低剂量造影剂的盲法研究，沿着盐水注射，由两名经验丰富的超声医师正确识别。本临床前研究建立了适当的设备设置和剂量，可有效证明正中神经周围的血管分布。
This preclinical study was conducted to develop discrete sonographic instrumentation settings and also safe contrast dosing that would consistently demonstrate perineural vascularity along the median nerve. This set of imaging studies was conducted with a convenience cohort of young adult female monkeys (Macaca fascicularis). Sonographic equipment settings and dosing were refined throughout the imaging series to ensure consistent contrast-enhanced ultrasound imaging. A mechanical index of 0.13 was consistently used for imaging. Perineural vessels were imaged with a suspension solution of 0.04 mL Definity/0.96 mL saline introduced over 5 minutes for a total dose of 0.8 mL of contrast solution. Blinded studies of high and low dose contrast, along with saline injections, were correctly identified by two experienced sonographers. This preclinical study established adequate equipment settings and dosing that allowed for a valid demonstration of vascularity surrounding the median nerve.