Nanomaterials and bone regeneration.
Nanomaterials and bone regeneration.
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DOI：
10.1038/boneres.2015.29
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发表时间：
2015
期刊：
影响因子：
12.7
通讯作者：
Lin Y
中科院分区：
文献类型：
--
作者：
Gong T;Xie J;Liao J;Zhang T;Lin S;Lin Y
骨疾病和病症的全球发病率一直在增加。骨是由有机（主要是胶原）和无机（主要是纳米羟基磷灰石）成分组成的纳米材料，具有从纳米尺度到宏观尺度的层次结构。鉴于传统治疗方法的严重局限性，纳米材料为骨再生提供了新的策略。纳米结构支架为细胞提供了更接近天然骨结构的结构支撑，并调节细胞增殖、分化和迁移，从而形成功能性组织。本文主要综述了骨再生纳米材料和纳米载体材料的分类、设计、细胞相互作用特性及其在骨组织工程和骨再生中的应用。最后在结论和展望部分对纳米材料在骨再生中的应用研究提出了一些新的挑战。
The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic (mainly collagen) and inorganic (mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from nanoscale to macroscale. In consideration of the serious limitation in traditional therapies, nanomaterials provide some new strategy in bone regeneration. Nanostructured scaffolds provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in the formation of functional tissues. In this article, we focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration. Furthermore, some new challenges about the future research on the application of nanomaterials for bone regeneration are described in the conclusion and perspectives part.