Dual trigger for final oocyte maturation improves the oocyte retrieval rate of suboptimal responders to gonadotropin-releasing hormone agonist
Dual trigger for final oocyte maturation improves the oocyte retrieval rate of suboptimal responders to gonadotropin-releasing hormone agonist
复制标题
最终卵母细胞成熟的双重触发提高了对促性腺激素释放激素激动剂反应不佳者的卵母细胞回收率
DOI：
10.1016/j.fertnstert.2016.07.1068
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发表时间：
2016-11-01
影响因子：
6.7
通讯作者：
Kuang, Yanping
中科院分区：
文献类型：
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作者：
Lu, Xuefeng;Hong, Qingqing;Kuang, Yanping
目的：为了确定促性腺激素释放激素激动剂（GnRH-a）触发的次优反应的风险因素，并评估hCG对GnRH-a次优反应患者结局的影响。设计：回顾性数据分析。设置：三级护理学术医疗中心。患者：共8，092名接受8，970个IVF/卵胞浆内单精子注射（ICSI）治疗周期的女性。干预措施：所有女性在IVF/ICSI期间接受hMG +醋酸甲羟孕酮（MPA）/P治疗周期，这些治疗周期单独使用GnRH-a或与hCG（1，000，2，000或5，000 IU）联合使用。主要结果测量：取卵率、成熟卵率、受精率、取卵数、成熟卵数和冷冻胚胎数。结果：总共有2.71%（243/8，970）的患者表现出对GnRH-a的次优反应。次优反应者（LH
Objective: To identify the risk factors for suboptimal response to GnRH agonist (GnRH-a) trigger and evaluate the effect of hCG on the outcome of patients with suboptimal response to GnRH-a.Design: A retrospective data analysis.Setting: A tertiary-care academic medical center.Patient(s): A total of 8,092 women undergoing 8,970 IVF/intracytoplasmic sperm injection (ICSI) treatment cycles.Intervention(s): All women underwent hMG + medroxyprogesterone acetate (MPA)/P treatment cycles during IVF/ICSI, which were triggered using a GnRH-a alone or in combination with hCG (1,000, 2,000, or 5,000 IU). Viable embryos were cryopreserved for later transfer.Main Outcome Measure(s): The rates of oocyte retrieval, mature oocytes, fertilization, and the number of oocytes retrieved, mature oocytes, and embryos frozen.Result(s): In total, 2.71% (243/8,970) of patients exhibited a suboptimal response to GnRH-a. The suboptimal responders (LH