A review of adsorption of amino acids on minerals: Was it important for origin of life?
A review of adsorption of amino acids on minerals: Was it important for origin of life?
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DOI：
10.1007/s00726-004-0106-4
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发表时间：
2004-07
期刊：
影响因子：
3.5
通讯作者：
D. Zaia
中科院分区：
文献类型：
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作者：
D. Zaia
矿物质比不带电荷的R基团更容易吸附带电荷的R基团的氨基酸，因此带电荷的R基团的氨基酸与肽的结合比不带电荷的R基团的氨基酸更频繁。然而，现代生物蛋白质中74%的氨基酸含有不带电荷的R基团。因此，产生具有更多不带电荷的R基团的氨基酸的肽/蛋白质比具有带电荷的R基团的前体的机制是什么？我们是否应该期望吸附在矿物质上的氨基酸的组成与目前蛋白质的组成相似？氨基酸吸附在矿物质上对生命的起源重要吗？脂质世界提供了生命起源的另一种观点。脂质体有助于肽的延伸以及选择疏水性氨基酸和肽。这些实验可以显示疏水氨基酸被选择的机制。然而，脂质体对氨基酸寡聚化的立体选择性没有影响。在本文中，还讨论了其他几种机制，可以产生更大比例的氨基酸与不带电荷的R基团的肽。
Minerals more readily adsorb amino acids with charged R groups than uncharged R groups, so that the incorporation of amino acids with charged R groups into peptides would be more frequent than for amino acids with uncharged R groups. However, 74% of the amino acids in the proteins of modern organisms contain uncharged R groups. Thus, what could have been the mechanisms that produced peptides/proteins with more amino acids with uncharged R groups than precursors with charged R groups? Should we expect the composition of amino acids adsorbed on minerals to be similar to those of present proteins? Was the adsorption of amino acids on minerals important for the origin of life? The lipid world offers an alternative view of origin of life. Liposomes contributed to elongation of peptides as well as select hydrophobic amino acids and peptides. These experiments could be showing the mechanism, which hydrophobic amino acids have been selected. However, liposomes have no influence on the stereoselectivity in the oligomerization of amino acids. In the present paper, several other mechanisms are also discussed that could produce peptides with a greater proportion of amino acids with uncharged R groups.