MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
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DOI：
10.1016/j.immuni.2012.12.006
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发表时间：
2013-04-18
期刊：
影响因子：
32.4
通讯作者：
Romero P
中科院分区：
文献类型：
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作者：
Dudda JC;Salaun B;Ji Y;Palmer DC;Monnot GC;Merck E;Boudousquie C;Utzschneider DT;Escobar TM;Perret R;Muljo SA;Hebeisen M;Rufer N;Zehn D;Donda A;Restifo NP;Held W;Gattinoni L;Romero P
MicroRNA调节几种免疫细胞的功能，但它们在促进CD 8 + T细胞免疫中的作用仍然未知。在这里，我们报告了miR-155是CD 8 + T细胞对病毒和癌症的反应所必需的。在缺乏miR-155的情况下，在急性和慢性病毒感染期间效应CD 8 + T细胞的积累严重减少，并且病毒复制的控制受损。类似地，miR-155-/-CD 8 + T细胞在控制肿瘤生长方面是有效的，而miR-155过表达增强了抗肿瘤反应。miR-155缺陷导致SOCS-1的积累，导致通过STAT 5的细胞因子信号传导缺陷。一致地，在CD 8 + T细胞中SOCS-1的增强表达表型模仿miR-155缺陷，而SOCS-1沉默增强肿瘤破坏。这些发现将miR-155及其靶点SOCS-1确定为效应CD 8 + T细胞的关键调节因子，可调节效应CD 8 + T细胞以增强感染性疾病和癌症的免疫治疗。
MicroRNAs regulate the function of several immune cells but their role in promoting CD8+ T-cell immunity remains unknown. Here we report that miR-155 is required for CD8+ T-cell responses to both virus and cancer. In the absence of miR-155, accumulation of effector CD8+ T cells was severely reduced during acute and chronic viral infections and control of virus replication was impaired. Similarly, Mir155-/- CD8+ T cells were in effective at controlling tumor growth, whereas miR-155 overexpression enhanced the antitumor response. miR-155 deficiency resulted in accumulation of SOCS-1 causing defective cytokine signaling through STAT5. Consistently, enforced expression of SOCS-1 in CD8+ T cells phenocopied the miR-155 deficiency, whereas SOCS-1 silencing augmented tumor destruction. These findings identify miR-155 and its target SOCS-1 as key regulators of effector CD8+ T cells that can be modulated to potentiate immunotherapies for infectious diseases and cancer.
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DOI：
10.1158/1078-0432.ccr-11-0503
发表时间：
2011-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Klebanoff CA;Gattinoni L;Palmer DC;Muranski P;Ji Y;Hinrichs CS;Borman ZA;Kerkar SP;Scott CD;Finkelstein SE;Rosenberg SA;Restifo NP
通讯作者：
Restifo NP
影响因子：
20.3
作者：
Jiang, Shan;Li, Chaoran;Li, Qi-Jing
通讯作者：
Li, Qi-Jing
影响因子：
64.8
作者：
Daniels, Mark A.;Teixeiro, Emma;Palmer, Ed
通讯作者：
Palmer, Ed
影响因子：
4.8
作者：
Cornish, AL;Chong, MM;Alexander, WS
通讯作者：
Alexander, WS
影响因子：
8
作者：
Kluiver, J.;van den Berg, A.;Kroesen, B-J
通讯作者：
Kroesen, B-J