Top-down feedback enables flexible coding strategies in the olfactory cortex
Top-down feedback enables flexible coding strategies in the olfactory cortex
复制标题
自上而下的反馈可以在嗅觉皮层中实现灵活的编码策略
DOI：
10.1016/j.celrep.2022.110545
复制
发表时间：
2022
期刊：
影响因子：
8.8
通讯作者：
Padmanabhan, Krishnan
中科院分区：
文献类型：
--
作者：
Chen, Zhen;Padmanabhan, Krishnan
在化学感觉中，已经提出了多种模型来解释气味是如何在嗅觉皮层中表现的。一个假设是，嗅觉相关的时间窗口内的活性神经元的组合身份是至关重要的，而另一个模型提出，这是神经活动的时间结构是编码气味信息是必不可少的。我们发现，自上而下的反馈到主嗅球决定了信息传输到梨状皮质，并在这些编码策略之间切换。使用一个详细的网络模型，我们表明，抑制的反馈控制影响兴奋-抑制二尖瓣细胞的平衡，重组梨状皮质细胞的动力学。这导致气味辨别任务的性能改善。这些发现为早期嗅觉计算提供了一个框架，其中对球的自上而下的反馈灵活地塑造了梨状皮质中神经活动的时间结构，使早期嗅觉系统能够在两种不同的编码模型之间动态切换。
In chemical sensation, multiple models have been proposed to explain how odors are represented in the olfactory cortex. One hypothesis is that the combinatorial identity of active neurons within sniff-related time windows is critical, whereas another model proposes that it is the temporal structure of neural activity that is essential for encoding odor information. We find that top-down feedback to the main olfactory bulb dictates the information transmitted to the piriform cortex and switches between these coding strategies. Using a detailed network model, we demonstrate that feedback control of inhibition influences the excitation-inhibition balance in mitral cells, restructuring the dynamics of piriform cortical cells. This results in performance improvement in odor discrimination tasks. These findings present a framework for early olfactory computation, where top-down feedback to the bulb flexibly shapes the temporal structure of neural activity in the piriform cortex, allowing the early olfactory system to dynamically switch between two distinct coding models.