The medium-term results of treatment with hydroxyapatite implants.
The medium-term results of treatment with hydroxyapatite implants.
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羟基磷灰石植入物治疗的中期结果。
DOI：
10.1002/jbm.b.30335
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
S. Niwa
中科院分区：
文献类型：
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作者：
K. Shibuya;H. Kurosawa;H. Takeuchi;S. Niwa
尽管含有合成羟基磷灰石（HA）（一种生物活性材料）的植入物的短期结果良好，但有关该疗法的中期结果的报告很少。作者最近分析了全国 37 家医疗机构提供的有关合成 HA 植入物结果的数据 [Bonfil (BF)；东京三菱材料公司]对 138 名患者进行了治疗后至少 5 年的随访。分析数据时，将患者分为两组：疾病部位填充组（62例由疾病造成的骨缺损用合成HA填充）和供体部位填充组（76例由骨捐赠造成的骨缺损用合成HA填充）。在病变部位填充组中，77%的病例将合成HA与同一患者捐赠的自体骨或自体骨髓结合使用。在供体位点填充组中，大多数情况下仅使用合成 HA。植入后的平均随访时间，疾病部位填充组为 7.9 年，供体部位填充组为 9.1 年。疾病部位填充组中 81% 的患者和供体部位填充组中 89% 的患者的放射照相治疗被评为“非常有效”或“有效”。在任何一组病例中，该疗法均未被评为“无效”。这些结果表明，如果谨慎使用，并考虑到其初始强度，合成 HA 可以作为松质骨的非常有用的替代品。
Although the short-term results of implants with synthetic hydroxyapatite (HA), a bioactive material, have been favorable, few reports have been published concerning medium-term outcomes for this therapy. The authors recently analyzed data supplied by 37 medical facilities nationwide concerning the outcomes of synthetic HA implants [Bonfil (BF); Mitsubishi Materials Corporation, Tokyo] in 138 patients followed up for at least 5 years after treatment. When the data were analyzed, the patients were divided into two groups: the disease site-filling group (62 cases where bone defects created by disease were filled with synthetic HA) and the donor site-filling group (76 cases where bone defects created by bone donation were filled with synthetic HA). In the disease site-filling group, synthetic HA was used in combination with autologous bone or autogenous bone marrow donated from the same patient in 77% of cases. In the donor site-filling group, only synthetic HA was used in most cases. The average follow-up period after implantation was 7.9 years in the disease site-filling group and 9.1 years in the donor site-filling group. Therapy was rated radiographically as "very effective" or "effective" in 81% of patients in the disease site-filling group and in 89% of patients in the donor site-filling group. The therapy was not rated as "ineffective" in any case from either group. These results suggest that synthetic HA may serve as a very useful substitute for cancellous bone if used carefully, with its initial strength taken into account.