Sex and age differences in sST2 in cardiovascular disease.
Sex and age differences in sST2 in cardiovascular disease.
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DOI：
10.3389/fcvm.2022.1073814
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
本研究的目的是确定可溶性ST 2（sST 2）在几种心血管疾病（CVD）中是否存在性别和年龄差异。我们使用ELISA试剂盒检测了心肌炎（n = 303）、心肌病（n = 293）、冠状动脉疾病（CAD）（n = 239）、心肌梗死（MI）（n = 159）和充血性心力衰竭（CHF）（n = 286）的sST 2水平，并将其与无心血管疾病的对照组（n = 234）进行了比较。在这项研究中，心肌炎发生在40岁左右的相对年轻的患者中，而其他心血管疾病更常发生在60岁左右的老年人中。我们仅在心肌炎患者（男性38岁，女性46岁，p = 0.0002）中观察到sST 2的年龄性别差异，但在其他心血管疾病中没有。与年龄匹配的对照组相比，所有CVD的血清sST 2水平均显著升高：心肌炎（p ≤ 0.0001），心肌病（p = 0.0009），CAD（p = 0.03），MI（p = 0.034）和CHF（p < 0.0001）由女性所有CVD的sST 2水平升高驱动，心肌炎除外，女性（p = 0.002）和男性（p ≤ 0.0001）均升高。在心肌炎和心肌病中发现sST 2水平存在性别差异，但在其他心血管疾病中没有发现sST 2水平的性别差异，并且男性的sST 2水平较高（心肌炎p = 0.0035;心肌病p = 0.0047）。与男性（p = 0.0004）或50岁以下女性（p = 0.015）相比，50岁以上心肌炎女性的sST 2水平更高。在心肌病和MI患者中，50岁以上的男性sST 2水平显著高于女性（分别为p = 0.012和p = 0.043），但在其他CVD中未检测到性别和年龄差异。然而，经历过早期绝经的心肌病妇女的sST 2水平高于在自然年龄范围内经历绝经的妇女（p = 0.02）。我们发现心肌炎、心肌病和MI患者血清sST 2存在性别和年龄差异，但在其他心血管疾病（包括CAD和CHF）中未观察到差异。这些在自报心血管疾病患者中的初步发现表明，需要对个体心血管疾病中sST 2水平的性别和年龄差异进行更多研究。
The goal of this study was to determine whether sex and age differences exist for soluble ST2 (sST2) for several cardiovascular diseases (CVDs). We examined sST2 levels using an ELISA kit for myocarditis (n = 303), cardiomyopathy (n = 293), coronary artery disease (CAD) (n = 239), myocardial infarct (MI) (n = 159), and congestive heart failure (CHF) (n = 286) and compared them to controls that did not have CVDs (n = 234). Myocarditis occurred in this study in relatively young patients around age 40 while the other CVDs occurred more often in older individuals around age 60. We observed a sex difference in sST2 by age only in myocarditis patients (men aged 38, women 46, p = 0.0002), but not for other CVDs. Sera sST2 levels were significantly elevated compared to age-matched controls for all CVDs: myocarditis (p ≤ 0.0001), cardiomyopathy (p = 0.0009), CAD (p = 0.03), MI (p = 0.034), and CHF (p < 0.0001) driven by elevated sST2 levels in females for all CVDs except myocarditis, which was elevated in both females (p = 0.002) and males (p ≤ 0.0001). Sex differences in sST2 levels were found for myocarditis and cardiomyopathy but no other CVDs and were higher in males (myocarditis p = 0.0035; cardiomyopathy p = 0.0047). sST2 levels were higher in women with myocarditis over 50 years of age compared to men (p = 0.0004) or women under 50 years of age (p = 0.015). In cardiomyopathy and MI patients, men over 50 had significantly higher levels of sST2 than women (p = 0.012 and p = 0.043, respectively) but sex and age differences were not detected in other CVDs. However, women with cardiomyopathy that experienced early menopause had higher sST2 levels than those who underwent menopause at a natural age range (p = 0.02). We found that sex and age differences in sera sST2 exist for myocarditis, cardiomyopathy, and MI, but were not observed in other CVDs including CAD and CHF. These initial findings in patients with self-reported CVDs indicate that more research is needed into sex and age differences in sST2 levels in individual CVDs.
影响因子：
4
作者：
Tago K;Ohta S;Kashiwada M;Funakoshi-Tago M;Matsugi J;Tominaga SI;Yanagisawa K
通讯作者：
Yanagisawa K