Enhancing magnetic hyperthermia in ferrite nanoparticles through shape anisotropy and surface hybridization
Enhancing magnetic hyperthermia in ferrite nanoparticles through shape anisotropy and surface hybridization
复制标题
DOI：
10.1002/aic.17437
复制
发表时间：
2021-09-23
期刊：
影响因子：
3.7
通讯作者：
Romero, Gabriela
中科院分区：
文献类型：
--
作者：
Jimenez, Gloria L.;Guntnur, Rohini Thevi;Romero, Gabriela
在过去的二十年里，磁热疗已经在癌症治疗中进行了研究，因为磁性纳米颗粒在施加的交变磁场下产生的局部热量足以杀死癌细胞。最近，它已被探索通过热敏跨膜通道控制生物信号。生产具有高热传导效率的磁性纳米颗粒以最小化潜在的脱靶加热效应是非常感兴趣的。在这里，我们描述了形状各向异性和粒子杂交作为可能的途径，以增强铁氧体纳米粒子的磁热疗。合成了不同尺寸的锌取代磁铁矿核和核壳结构的立方纳米粒子。结果发现，纳米颗粒的形状和组成从立方改变到花状，并随着尺寸的增加而变成更富的相。与钴壳的杂交允许增强纳米颗粒的磁性和比功率损耗。测试优化的核-壳纳米颗粒在海马神经元中诱导细胞活性。无机材料：合成与加工。
Magnetic hyperthermia has been studied for the past two decades in cancer treatments as the local heat generated by magnetic nanoparticles under applied alternating magnetic fields is sufficient to kill cancer cells. More recently, it has been explored for controlling biological signaling through heat-sensitive transmembrane channels. It is of great interest to produce magnetic nanoparticles with high heat transducing efficiency to minimize potential off-target heating effects. Here, we describe shape anisotropy and particle hybridization as possible routes to augment magnetic hyperthermia in ferrite nanoparticles. Zinc substituted magnetite core and core-shell cubic nanoparticles with different sizes were synthetized. It was found that nanoparticles shape and composition are altered from cubic to flower-like, and to a more franklinite rich phase as size increased. Hybridization with a cobalt shell allowed to enhance nanoparticle magnetic coercivity and specific power loss. The optimized core-shell nanoparticles were tested to induce cellular activity in hippocampal neurons. TOPICAL HEADING Inorganic Materials: Synthesis and Processing.