Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle
Progress on meiotic gene expression and epigenetic regulation of male sterility in Dzo cattle
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DOI：
10.16288/j.yczz.20-176
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发表时间：
2020-11-01
期刊：
影响因子：
--
通讯作者：
Zhang, Gongwei
中科院分区：
文献类型：
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作者：
Chen, Huiyou;Zhang, Jianmin;Zhang, Gongwei
种间杂种雄性不育是自然界中常见的现象，在物种生殖隔离中起着重要作用。牦牛是家牦牛（Bos grunniens）与普通牛（Bos taurus）种间杂交的后代，是研究种间杂种雄性不育的独特动物模型。Dzo女性是完全可育的，而男性是不育的。近年来的分子生物学研究表明，与黄牛或牦牛相比，Dzo精巢减数分裂过程中基因表达失调。其他研究表明，表观遗传因素/事件，如DNA甲基化，组蛋白修饰和非编码RNA，也参与精子发生。本文综述了Dzo睾丸减数分裂过程中基因表达、DNA甲基化、microRNA（miRNA）、PIWI相互作用RNA（皮尔纳）、长链非编码RNA（lncRNA）和组蛋白甲基化修饰等方面的研究进展。这些结果揭示了Dzo精巢减数分裂的遗传和表观遗传调控的潜在作用，从而对种间杂种雄性不育的分子机制提供了更详细的认识。
Interspecific hybrid male sterility is a common occurrence in nature and plays an important role in species reproductive isolation. Dzo (cattle-yak), the offspring of interspecific cross between domestic yak (Bos grunniens) and cattle (Bos taurus), is a unique animal model for investigating interspecific hybrid male sterility. Dzo females are completely fertile while the males are sterile. In recent years, molecular studies have demonstrated that the expressions of genes were dysregulated during meiosis in Dzo testis, as compared to those in cattle or yak. Other studies have revealed that epigenetic factors/events, such as DNA methylation, histone modification and non-coding RNA, are also involved in spermatogenesis. This review summarizes the dysregulation of gene expression, DNA methylation, microRNA (miRNA), PIWI-interacting RNA (piRNA), long non-coding RNA (lncRNA), and histone methylation modification during meiosis in Dzo testis. These results highlighted the potential roles of genetic and epigenetic regulations of meiosis in Dzo testis, thereby providing a more detailed understanding on the molecular mechanisms of interspecific hybrid male sterility.