The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.
The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.
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DOI：
10.4161/viru.26400
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发表时间：
2014-01-01
期刊：
影响因子：
5.2
通讯作者：
Sriskandan S
中科院分区：
文献类型：
--
作者：
Reglinski M;Sriskandan S
化脓性链球菌（A组链球菌，GAS）是导致从轻度咽炎和脓疱到严重侵入性软组织感染的广泛病理的原因。尽管细菌对β-内酰胺类抗生素持续敏感，但在过去30年中，侵袭性GAS感染的患病率出现了无法解释的复苏。特别重要的是出现了与产TSST-1金黄色葡萄球菌菌株相关的全身中毒类似的气体相关脓毒症综合征。尽管认识到超过20年，GAS相关脓毒症和链球菌中毒性休克综合征的病因仍然知之甚少。在这里，我们审查的毒力因子，有助于GAS相关的脓毒症的病因，特别关注凝血系统的相互作用和超抗原在链球菌中毒性休克综合征的发展中的作用。
Streptococcus pyogenes (group A streptococcus, GAS) is responsible for a wide range of pathologies ranging from mild pharyngitis and impetigo to severe invasive soft tissue infections. Despite the continuing susceptibility of the bacterium to β-lactam antibiotics there has been an unexplained resurgence in the prevalence of invasive GAS infection over the past 30 years. Of particular importance was the emergence of a GAS-associated sepsis syndrome that is analogous to the systemic toxicosis associated with TSST-1 producing strains of Staphylococcus aureus. Despite being recognized for over 20 years, the etiology of GAS associated sepsis and the streptococcal toxic shock syndrome remains poorly understood. Here we review the virulence factors that contribute to the etiology of GAS associated sepsis with a particular focus on coagulation system interactions and the role of the superantigens in the development of streptococcal toxic shock syndrome.