EFFECTS ON INTACT FEMORA OF DOGS OF APPLICATION AND REMOVAL OF METAL PLATES - METABOLIC AND STRUCTURAL STUDY COMPARING STIFFER AND MORE FLEXIBLE PLATES
EFFECTS ON INTACT FEMORA OF DOGS OF APPLICATION AND REMOVAL OF METAL PLATES - METABOLIC AND STRUCTURAL STUDY COMPARING STIFFER AND MORE FLEXIBLE PLATES
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DOI：
10.2106/00004623-197860070-00012
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发表时间：
1978-01-01
影响因子：
5.3
通讯作者：
HARRIS, WH
中科院分区：
文献类型：
--
作者：
MOYEN, BJL;LAHEY, PJ;HARRIS, WH
对柔性塑料板的研究表明，与刚性金属板相比，柔性塑料板下面的骨质疏松症发病率更低。迄今为止，具有适当物理性能和生物相容性的塑料板还不能用于人体。为了确定使用金属板是否可以获得类似的有益效果，在狗身上的实验中，将厚Cr-Co板的效果与由Ti， 6-Al， 4-V制成的类似设计的较薄板的效果进行了对比。使用更灵活的钢板可显著减少骨质疏松症。钢板应用后，骨内、骨膜和皮质内对骨形成产生延迟的、大量的、短暂的刺激。尽管如此，骨量的大量减少发生了，主要是由骨内吸收介导的。皮质内孔隙率在净骨质流失中几乎没有作用。主要的影响在6个月后消退。钢板取出后的恢复主要是骨内新骨形成的结果。
Studies of flexible plates made of plastic have shown that less osteoporosis develops beneath them than beneath rigid metal plates. To date plastic plates of appropriate physical properties and biocompatibility are not available for use in humans. To determine if a similar beneficial effect could be obtained using metal plates, the effects of thick Cr-Co plates were contrasted in experiments in dogs with the effects of thinner plates of similar design made of Ti, 6-Al, 4-V. A significant reduction in the osteoporosis was obtained by use of the more flexible plates. Following plate application a delayed, massive, transient stimulus to bone formation occurred endosteally, periosteally and intracortically. Despite this, a substantial decrease in bone mass occurred, primarily mediated by endosteal bone resorption. Intracortical porosity played little or no role in net bone loss. The major effects subsided by 6 mo. Recovery after plate removal was predominantly the result of endosteal new bone formation.