Staphylococcus pseudintermedius Human Infection Cases in Spain: Dog-to-Human Transmission
Staphylococcus pseudintermedius Human Infection Cases in Spain: Dog-to-Human Transmission
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DOI：
10.1089/vbz.2016.2048
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发表时间：
2017-04-01
影响因子：
2.1
通讯作者：
Torres, Carmen
中科院分区：
文献类型：
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作者：
Lozano, Carmen;Rezusta, Antonio;Torres, Carmen
假中间葡萄球菌是一种条件致病菌，已被确定为主要在犬中的感染因子或定殖者。S.在人类中，更具体地说，在与狗接触的人中也检测到了假中间体。在这项研究中，可能的S。在四个临床人类病例中分析了伪中间体宠物到人的传播。2例患者为养狗者和S.在这些健康动物中也检测到伪中间体作为定殖体。S.来自同一家庭的患者和狗的假中间体分离株显示相同的脉冲场凝胶电泳模式，序列类型（ST），抗菌药物耐药表型和基因型，甲氧西林敏感。沙门氏菌对红霉素、克林霉素、四环素、曲美他滨-磺胺甲恶唑和/或环丙沙星耐药。pseudintermedius菌株。在两名狗主人患者的菌株中分别检测到谱系ST 241和新ST 521。另外两名患者的菌株呈现两种新的ST，ST 719和ST 720。据我们所知，这是第一次描述由S. pseudintermedius在西班牙
Staphylococcus pseudintermedius is an opportunistic pathogen that has been identified as infectious agent or colonizer mainly in dogs. S. pseudintermedius has been also detected in humans and more specifically in people in contact with dogs. In this study, the possible S. pseudintermedius pet-to-human transmission was analyzed in four clinical human cases. Two patients were dog owners and S. pseudintermedius was also detected as colonizer in these healthy animals. S. pseudintermedius isolates from patients and dogs of the same household showed identical pulsed-field gel electrophoresis patterns, sequence types (STs), and antimicrobial resistance phenotypes and genotypes, and were methicillin susceptible. Resistance to erythromycin, clindamycin, tetracycline, trimetoprim-sulfamethoxazole, and/or ciprofloxacin was identified among S. pseudintermedius strains. The lineages ST241 and the new ST521 were detected in the strains of the two dog-owner patients, respectively. The strains from the other two patients presented two new STs, ST719 and ST720. To our knowledge, this is the first description of human infections caused by S. pseudintermedius in Spain.