Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides.
Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides.
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通过以人参皂苷为重点的肠道微生物群增强草药补充剂的生物活性。
DOI：
10.1142/s0192415x11009433
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Li P
中科院分区：
文献类型：
--
作者：
Wang HY;Qi LW;Wang CZ;Li P
肠道微生物群有助于多种哺乳动物过程，包括药物的代谢功能。这是一个潜在的药物靶向新领域，特别是对于膳食草药产品。由于大多数草药是口服给药，因此草药的化学特征和相应的生物活性可能会被肠道微生物群改变。人参是最常用的草药之一，它总是一种有吸引力的天然产品。本文在简要介绍中药制剂与肠道菌群相互作用的基础上，重点讨论了肠道菌群对人参和红参中皂苷代谢的影响。特别是，主要代谢产物化合物K及其药理学进展进行了评论，包括抗癌，抗糖尿病和抗肿瘤作用。综上所述，肠道菌群可能在介导中草药的代谢和增强其生物活性方面发挥重要作用。
Intestinal microbiota contributes to diverse mammalian processes including the metabolic function of drugs. It is a potential new territory for drug targeting, especially for dietary herbal products. Because most of herbal drugs are orally administered, the chemical profile and corresponding bioactivities of herbal medicines may be altered by intestinal microbiota. Ginseng is one of the most commonly used herb and it is always an attractive natural product to understand. In this review, after briefly introduce the interactions of herbal products and gut microbiota, we discussed the microbiota-mediated metabolism of ginsenosides in ginseng and red ginseng. In particular, the major metabolite Compound K and its pharmacological advances are commented including anticancer, antidiabetic and antiinflammatory effects. In summary, the intestinal microbiota may play an important role in mediating the metabolism and enhancement of bioactivity of herbal medicines.