Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children
Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children
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DOI：
10.1111/j.1365-3156.2007.01988.x
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发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Polman, Katja
中科院分区：
文献类型：
--
作者：
Wordemann, Meike;Diaz, Raquel Junco;Polman, Katja
目的探讨过去和现在的肠道蠕虫感染与哮喘，过敏性鼻结膜炎，特应性皮炎和atopy.METHODS的1320名4-14岁的儿童从两个古巴城市的横断面研究的关系。通过粪便检查和父母问卷调查确定蠕虫感染。哮喘、鼻结膜炎和特应性皮炎的诊断采用国际儿童哮喘和过敏研究问卷，哮喘还采用肺量测定法，特应性皮炎采用皮肤点刺试验。根据肺量测定法，4%有哮喘; 20%有阳性皮肤点刺试验。蛲虫感染史与特应性皮炎（OR 1.88，P = 0.001）和过敏性鼻结膜炎（OR 1.34，P = 0.046）的风险增加相关，钩虫感染史与过敏性鼻结膜炎的风险增加相关（OR 2.77，P = 0.021）。蛔虫感染粪便检查阳性与特应性皮炎呈负相关（OR 0.22，P = 0.007）。哮喘和特应性与蠕虫感染无关。在古巴儿童中，蛔虫感染可预防特应性皮炎，而既往感染E.蛔虫和钩虫是过敏性鼻结膜炎和/或特应性皮炎的危险因素。显然，根据蠕虫和特应性疾病的类型以及蠕虫感染的时间，相互作用有所不同。
OBJECTIVE To examine the relationship of past and current intestinal helminth infections with asthma, allergic rhinoconjunctivitis, atopic dermatitis and atopy.METHODS Cross-sectional study of 1320 children aged 4-14 years from two Cuban municipalities. Helminth infections were determined by stool examination and parental questionnaire. Asthma, rhinoconjunctivitis and atopic dermatitis were diagnosed by International Study of Asthma and Allergies in Childhood questionnaire, asthma additionally by spirometry, atopy by skin prick testing.RESULTS Questionnaire-based frequencies were 21% for asthma, 14% for allergic rhinoconjunctivitis and 8% for atopic dermatitis. According to spirometry, 4% had asthma; 20% had a positive skin prick test. A history of infection for Enterobius vermicularis was associated with increased risk of atopic dermatitis (OR 1.88, P = 0.001) and allergic rhinoconjunctivitis (OR 1.34, P = 0.046), and hookworm with increased risk of allergic rhinoconjunctivitis (OR 2.77, P = 0.021). A positive stool examination for Ascaris lumbricoides infection was negatively associated with atopic dermatitis (OR 0.22, P = 0.007). Asthma and atopy were unrelated to helminth infections.CONCLUSION Current A. lumbricoides infection protects against atopic dermatitis in Cuban children, while past infection with E. vermicularis and hookworm are risk factors for allergic rhinoconjunctivitis and/or atopic dermatitis. Apparently, interactions differ depending on the type of helminth and atopic disease and on the time of helminth infestation.