CORRELATION OF RADIOTHERAPEUTIC PARAMETERS AND TREATMENT RELATED MORBIDITY - ANALYSIS OF RTOG STUDY 77-06
CORRELATION OF RADIOTHERAPEUTIC PARAMETERS AND TREATMENT RELATED MORBIDITY - ANALYSIS OF RTOG STUDY 77-06
复制标题
DOI：
10.1016/0360-3016(87)90038-1
复制
发表时间：
1987-07-01
影响因子：
7
通讯作者：
PIDCOCK, GM
中科院分区：
文献类型：
--
作者：
PILEPICH, MV;ASBELL, SO;PIDCOCK, GM
本报告是对RTOG 77-06中治疗相关发病率的更新和详细分析，RTOG 77-06是一项III期随机研究，在无淋巴结受累证据的A2期和B期前列腺癌患者中比较前列腺放疗与盆腔放疗后前列腺加强治疗。从1978年到1983年，当研究结束时，总共有453个可分析的病例。所有治疗相关发病病例均按严重程度分类（使用临床严重程度分级系统）。然后将这些数据与一些辐射参数（包括治疗体积（场）、剂量和技术）相关联。总的来说，与仅前列腺照射相比，盆腔照射与治疗相关发病率的显著增加无关。在本研究中使用的盆腔剂量范围内，未检测到显著的剂量效应。前列腺总剂量超过7000 cGy与直肠出血风险增加相关。某些治疗技术（盆腔淋巴管AP/PA照射）与肠道并发症的发生率增加有关。
The current report is an updated and detailed analysis of treatment related morbidity in RTOG 77-06, a Phase III randomized study comparing prostatic irradiation versus pelvic irradiation followed by a prostatic boost, in patients with Stage A2 and B carcinoma of the prostate without evidence of nodal involvement. A total of 453 analyzable cases were accrued from 1978 to 1983, when the study was closed. All cases of treatment related morbidity were classified as to severity (using a clinical severity grading system). The data were then correlated with a number of radiotherapeutic parameters including treatment volumes (fields), doses, and techniques. Overall, pelvic irradiation, compared to prostate irradiation only, was not associated with a significantly increased incidence of treatment related morbidity. Within the range of pelvic doses used in this study a significant dose effect could not be detected. Total doses to the prostate of more than 7000 cGy were associated with an increased risk of rectal bleeding. Certain treatment techniques, (AP/PA irradiation of the pelvic lymphatics) were associated with an increased incidence of bowel complications.