Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells.
Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells.
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DOI：
10.1111/jcmm.12822
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发表时间：
2016-05
影响因子：
5.3
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Cui Y;Sun Q;Liu Z
空气污染是对公众健康的一项重大挑战。环境细颗粒物（PM）是空气污染的关键成分，并与显著的死亡率相关。暴露于PM后的大部分死亡与心血管疾病有关。然而，PM暴露对心血管系统产生不良影响的机制在很大程度上仍然未知，且正在积极研究中。内皮功能障碍或损伤被认为是导致动脉粥样硬化和冠心病等心血管疾病发展的主要因素之一。内皮祖细胞（EPCs）在维持血管结构和功能的完整性方面起着关键作用。颗粒物暴露显著抑制了动物和人类中EPCs的数量和功能。然而，PM对EPCs有害影响的机制仍有待完全明确。其中一个重要机制可能与活性氧（ROS）水平升高和炎症有关。骨髓（BM）是EPCs的一个主要来源。因此，EPCs的数量和功能可能与骨髓中干细胞（SCs）的数量和功能状态密切相关。骨髓干细胞和其他干细胞具有心血管再生和修复的潜力。本综述重点总结了PM暴露对EPCs和SCs的有害影响，以及包括ROS形成在内的潜在机制和临床意义。
Air pollution is a major challenge to public health. Ambient fine particulate matter (PM) is the key component for air pollution, and associated with significant mortality. The majority of the mortality following PM exposure is related to cardiovascular diseases. However, the mechanisms for the adverse effects of PM exposure on cardiovascular system remain largely unknown and under active investigation. Endothelial dysfunction or injury is considered one of the major factors that contribute to the development of cardiovascular diseases such as atherosclerosis and coronary heart disease. Endothelial progenitor cells (EPCs) play a critical role in maintaining the structural and functional integrity of vasculature. Particulate matter exposure significantly suppressed the number and function of EPCs in animals and humans. However, the mechanisms for the detrimental effects of PM on EPCs remain to be fully defined. One of the important mechanisms might be related to increased level of reactive oxygen species (ROS) and inflammation. Bone marrow (BM) is a major source of EPCs. Thus, the number and function of EPCs could be intimately associated with the population and functional status of stem cells (SCs) in the BM. Bone marrow stem cells and other SCs have the potential for cardiovascular regeneration and repair. The present review is focused on summarizing the detrimental effects of PM exposure on EPCs and SCs, and potential mechanisms including ROS formation as well as clinical implications.