ACQUIRED RESISTANCE TO PROGUANIL IN PLASMODIUM-KNOWLESI
ACQUIRED RESISTANCE TO PROGUANIL IN PLASMODIUM-KNOWLESI
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DOI：
10.1016/0035-9203(52)90023-0
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发表时间：
1952-01-01
影响因子：
2.2
通讯作者：
NAIR, CP
中科院分区：
文献类型：
--
作者：
SINGH, J;RAY, AP;NAIR, CP
诺氏疟原虫可能通过一年内的间歇性暴露而获得对普罗格尼治疗的高度抗性。该电阻在间隔8个月后仍然明显。从最后一次曝光。这种耐药菌株对达拉匹林和溴胍也是难治的，但对磺胺嘧啶、氯喹或M3349不是。
P. knowlesi may acquire a high degree of resistance to progaunil therapy through intermittent exposures during the period of a year. This resistance was still evident after an interval of 8 mos. from the last exposure. This resistant strain was also refractory to daraprim and bromoguanide, but not to sulfadiazine, chloroquin or M3349.