Socioeconomic Disadvantage and the Pace of Biological Aging in Children
Socioeconomic Disadvantage and the Pace of Biological Aging in Children
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DOI：
10.1542/peds.2020-024406
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发表时间：
2021-06-01
期刊：
影响因子：
8
通讯作者：
Harden, K. Paige
中科院分区：
文献类型：
--
作者：
Raffington, Laurel;Belsky, Daniel W.;Harden, K. Paige
背景和目的：在社会经济劣势环境中长大的儿童在其一生中面临着更大的疾病和残疾负担。这种负担增加的一种假设机制是，生命早期的不利因素加速了衰老的生物过程，增加了对随后疾病的脆弱性。为了评估这一假设和预防干预的潜在影响，需要采取措施，量化儿童时期生物衰老的早期加速。方法：对参加德克萨斯双胞胎计划的N = 600名8至18岁的儿童和青少年（48%为女性）进行唾液DNA甲基化和社会经济环境的测量。我们使用DunedinPoAm DNA甲基化算法来测量生物衰老的速度，该算法用于量化与衰老相关的系统完整性下降的速度。我们测试了贫困家庭和社区的孩子是否比富裕家庭和社区的孩子衰老得更快。结果：生活在弱势家庭和社区的儿童表现出更快的dunedinpoam测量的衰老速度（r = 0.18；两者P = 0.001）。与白人和拉丁裔白人儿童相比，拉丁裔儿童表现出更快的邓尼丁波姆测量的衰老速度，这与该组中较高的劣势水平一致。青春期发育越早、身体质量指数越高、接触烟草越多的儿童，其衰老速度也越快。然而，DunedinPoAm测量的老龄化与社会经济劣势相关的速度对这些因素的控制是稳健的。结论：在社会经济劣势条件下成长的儿童表现出更快的生物衰老速度。DNA甲基化的衰老速度可能是有用的替代终点在评估方案和政策，以解决终身健康差距的童年社会决定因素。
BACKGROUND AND OBJECTIVES: Children who grow up in socioeconomic disadvantage face increased burden of disease and disability throughout their lives. One hypothesized mechanism for this increased burden is that early-life disadvantage accelerates biological processes of aging, increasing vulnerability to subsequent disease. To evaluate this hypothesis and the potential impact of preventive interventions, measures are needed that can quantify early acceleration of biological aging in childhood.METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in N = 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas Twin Project. We measured pace of biological aging using the DunedinPoAm DNA methylation algorithm, developed to quantify the pace-of-aging-related decline in system integrity. We tested if children in more disadvantaged families and neighborhoods exhibited a faster pace of aging as compared with children in more affluent contexts.RESULTS: Children living in more disadvantaged families and neighborhoods exhibited a faster DunedinPoAm-measured pace of aging (r = 0.18; P = .001 for both). Latinx-identifying children exhibited a faster DunedinPoAm-measured pace of aging compared with both White- and Latinx White-identifying children, consistent with higher levels of disadvantage in this group. Children with more advanced pubertal development, higher BMI, and more tobacco exposure exhibited faster a faster DunedinPoAm-measured pace of aging. However, DunedinPoAm- measured pace of aging associations with socioeconomic disadvantage were robust to control for these factors.CONCLUSIONS: Children growing up under conditions of socioeconomic disadvantage exhibit a faster pace of biological aging. DNA methylation pace of aging might be useful as a surrogate end point in evaluation of programs and policies to address the childhood social determinants of lifelong health disparities.