Changes in markers of alcohol intake in man below 'safe' drinking levels.
Changes in markers of alcohol intake in man below 'safe' drinking levels.
复制标题
男性酒精摄入量指标的变化低于“安全”饮酒水平。
DOI：
10.1093/oxfordjournals.alcalc.a045319
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发表时间：
1992
影响因子：
2.8
通讯作者：
J. Masarei
中科院分区：
文献类型：
--
作者：
V. Burke;I. Puddey;L. Beilin;R. Vandongen;J. Masarei
在一组343名工人中，只有34人每天定期饮用超过60毫升的乙醇，逻辑回归被用来确定生物标志物的组合，最好区分那些每天定期饮用少于30毫升或30毫升或更多乙醇的人。指标包括载脂蛋白A-II、尿酸、γ-谷氨酰转肽酶和平均红细胞体积。即使这些受试者报告的酒精摄入水平相对较低（使用7天回顾性酒精日记进行评估），酒精摄入量较高或较低的组也被分离，灵敏度为68%，特异性为74%，阳性预测值为71%。根据年龄和体重指数调整后的收缩压与酒精摄入量也呈线性相关，当纳入生物标志物指数时，正确分类的比例从71%提高到75%。仅使用生物标志物，94%的受试者每天定期饮用至少80 ml乙醇当量，100%的非饮酒者被正确分类。
In a group of 343 working men, only 34 of whom regularly drank more than 60 ml of ethanol per day, logistic regression was used to determine the combination of biomarkers which best discriminated between those who regularly drank less than 30 ml or 30 ml or more of ethanol daily. The index consisted of apolipoprotein A-II, uric acid, gamma-glutamyl transpeptidase and mean corpuscular volume. Even with the relatively low level of alcohol intake reported in these subjects (assessed using a 7-day retrospective alcohol diary), the groups with higher or lower intake of alcohol were separated with a sensitivity of 68%, a specificity of 74% and a positive predictive value of 71%. Systolic blood pressure, adjusted for age and body mass index, was also linearly related to alcohol intake, and when included in the biomarker index improved the proportion correctly classified from 71% to 75%. Using the biomarkers only, 94% of subjects regularly drinking at least 80 ml of ethanol equivalent per day and 100% of the non-drinkers were correctly classified.