Psychiatric syndromes in Huntington's disease.
Psychiatric syndromes in Huntington's disease.
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亨廷顿病的精神综合症。
DOI：
10.1176/ajp.140.6.728
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Shoulson,I
中科院分区：
文献类型：
--
作者：
Caine,ED;Shoulson,I
30例患有亨廷顿病（一种可以可靠诊断的遗传性神经精神疾病）的患者进行了系统的精神病理学评估，并进行了长时间的随访，必要时进行了精神药理学药物治疗。DSM-III标准用于建立综合征诊断。24个人表现出实质性的行为异常，包括情感和精神分裂症综合征，人格的变化，以及无法充分分类的疾病。药物治疗在某些情况下是适度有益的。考虑到在这一病因统一的疾病中遇到的一系列行为障碍表明，症状分类的维度方法可能比目前的类型学方法更有用。
Thirty patients with Huntington's disease, a genetically transmitted neuropsychiatric disorder that can be diagnosed reliably, were evaluated systematically for psychopathology, followed for extended periods, and treated with psychopharmacological medications when necessary. DSM-III criteria were used for establishing syndromic diagnoses. Twenty-four individuals demonstrated substantial behavioral abnormalities, including affective and schizophrenic syndromes, changes of personality, and disorders that could not be classified adequately. Pharmacotherapy was modestly beneficial in some cases. Consideration of the array of behavioral disturbances encountered in this pathogenetically unified disorder suggests that a dimensional approach to symptom classification might prove more useful heuristically than present typological methods.