The role of the StAR protein in steroidogenesis: challenges for the future
The role of the StAR protein in steroidogenesis: challenges for the future
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DOI：
10.1677/joe.0.1640247
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发表时间：
2000-03-01
影响因子：
4
通讯作者：
Stocco, DM
中科院分区：
文献类型：
--
作者：
Stocco, DM
甾体源性急性调节蛋白或StAR蛋白已被证明在类固醇激素生物合成的急性调节中起重要作用，通过其介导胆固醇向线粒体内膜和胆固醇侧链切割酶系统的转移。自1994年克隆以来，已经进行了许多研究，强调了该蛋白在类固醇形成中的重要作用。虽然现在很明显，StAR符合早期研究提出的急性调节标准，但几个关键领域仍然知之甚少。迄今为止，在将胆固醇转移到P450scc酶的过程中，StAR的作用机制是最棘手的。第二个应该引起极大兴趣的领域是进一步了解StAR基因的调控，它像许多基因一样非常复杂。最后，随着最近StAR在大脑中存在的证明，确定StAR是否在神经类固醇的合成中起作用应该被证明是非常重要的。
The steroidogenic acute regulatory or StAR protein has been shown to be instrumental in the acute regulation of steroid hormone biosynthesis through its action in mediating cholesterol transfer to the inner mitochondrial membrane and the cholesterol side chain cleavage enzyme system. Since the time of its cloning in 1994, a number of studies have been performed which underscore the important role that this protein plays in steroidogenesis. While it is now quite apparent that StAR fulfills the criteria for the acute regulator as proposed by early studies, several crucial areas remain poorly understood. This list is topped by the so far intractable nature of the mechanism of action of StAR in transferring cholesterol to the P450scc enzyme. A second area which should prove to be of great interest is that of further understanding the regulation of the StAR gene which, like many genes, is quite complex. Lastly, with the recent demonstration of StAR being present in the brain, determining if StAR has a role in the synthesis of neurosteroids should prove to be of great: importance.