LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS.
LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS.
复制标题
DOI：
10.1097/shk.0000000000001958
复制
发表时间：
2022-07-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
目的：我们之前在创伤患者中发现了两种转录组亚型（签名组：SG1和SG2），其中SG1与更差的结局相关。在这项研究中，我们的目的是进一步描述创伤患者SG亚型分类在受伤后随时间的变化，并根据亚型指定的时间确定与结局的相应关联。方法和结果：本研究是对已发表的全血白细胞转录组学数据的二次分析，这是来自167例严重钝性创伤患者的纵向数据。我们将创伤患者分为SG1或SG2亚型，时间点为伤后12小时至28天（含），并描述其纵向结局。SG1分配（无论时间点如何）始终与恢复较慢相关。进一步分析显示，通过评估12小时和1天的SG亚型，可以获得额外的预后信息。结论：这项研究提供了一个概念的证据，免疫状态可以恶化后入院，并强调纵向监测SG亚型的创伤患者的好处。
Objective: We previously identified two transcriptomic subtypes (Signature Groups: SG1 vs. SG2) in trauma patients at 12 hours postinjury, with SG1 associated with worse outcomes. In this study, we aimed to further characterize the changes in SG subtype categorization of trauma patients over time after injury and define the corresponding association with outcomes based on the timing of the subtype designation. Methods and Results: This study was a secondary analysis of published data of whole-blood leukocyte transcriptomics, a longitudinal data from 167 severe blunt trauma patients. We assigned trauma patients to SG1 or SG2 subtype for time points between 12 hours and 28 days, inclusive, postinjury and characterized their longitudinal outcomes. SG1 assignment, regardless of time point, was associated consistently with slower recovery. Further analysis revealed that additional prognostic information could be obtained by assessing SG subtype at both 12 hours and 1 day. Conclusions: This study provides a proof of concept that immune status can worsen after admission and highlights the benefit of longitudinally monitoring SG subtypes in trauma patients.