CAPSULATION OF PNEUMOCOCCUS WITH SOLUBLE C-LIKE (CS) POLYSACCHARIDE .I. BIOLOGICAL AND GENETIC PROPERTIES OF CS PNEUMOCOCCAL STRAINS
CAPSULATION OF PNEUMOCOCCUS WITH SOLUBLE C-LIKE (CS) POLYSACCHARIDE .I. BIOLOGICAL AND GENETIC PROPERTIES OF CS PNEUMOCOCCAL STRAINS
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DOI：
10.1084/jem.128.6.1385
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发表时间：
1968-01-01
影响因子：
15.3
通讯作者：
AUSTRIAN, R
中科院分区：
文献类型：
--
作者：
BORNSTEIN, DL;SCHIFFMAN, G;AUSTRIAN, R
已从该生物体的几种非包囊化变体中分离出产生与肺炎球菌的C或细胞壁多糖免疫相关的可溶性多糖包囊的肺炎球菌包囊化突变体。这些菌株的荚膜材料与肺炎球菌的同源菌株和非荚膜菌株的抗血清以及与人C反应蛋白反应。C-反应蛋白可与肺炎球菌变异株产生阳性荚膜沉淀素或Quellung反应，并使其凝集。决定产生Cspolysaccharide的基因位点位于肺炎球菌染色体上，与控制正常荚膜多糖合成的区域不同。在DNA介导的转化后，已经分离出二元和三元荚膜肺炎球菌，其荚膜组分之一是Cspolysaccharide。
Capsulated mutants of pneumococcus producing a capsule of soluble polysaccharide related immunologically to the C or cell wall polysaccharide of pneumococcus have been isolated from several noncapsulated variants of this organism. The capsular material of these strains reacts with antisera both to homologous strains and to noncapsulated strains of pneumococcus and with human C-reactive protein. C-reactive protein has been shown to give a positive capsular precipitin or Quellung reaction with Cspneumococcal variants and to agglutinate them.The genetic locus which determines the production of Cspolysaccharide is situated in a region of the pneumococcal chromosome distinct from that controlling normal capsular polysaccharide synthesis. Binary and ternary capsulated pneumococci, one of the capsular components of which is Cspolysaccharide, have been isolated following DNA-mediated transformation.