Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
复制标题
年龄和抗癫痫药物对氯巴扎姆和 N-去甲基氯巴扎姆血浆水平和动力学的影响。
DOI：
10.1111/j.1600-0773.1990.tb00799.x
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
J. Cano
中科院分区：
文献类型：
--
作者：
H. Bun;S. Monjanel;F. Noel;A. Durand;J. Cano
作者监测了400多名接受不同合并用药（如苯妥英（PH）、卡马西平（CBZ）、丙戊酸钠（VPA）和苯巴比妥（PB））的癫痫患者长期治疗期间氯巴占（CLO）及其主要代谢产物N-去甲基氯巴占（NCLO）的血浆水平。本研究探讨了年龄和抗癫痫药物对血浆CLO和NCLO水平的影响。CLO早晨给药后3小时测量的血浆浓度范围为30 - 700 [公式;见正文]（CLO）和160 - 7000 [公式;见正文]（NCLO）。20-30岁患者的血浆CLO水平较高。NCLO浓度随着年龄的增长而增加，直到20岁。共同管理的抗癫痫化合物显着降低CLO的最大血浆水平。此外，PH和CBZ a显著增加血浆NCLO水平。CBZ对CLO动力学影响的结果在接受PB和VPA以及随后PB、VPA和CBZ作为CLO相关药物的10例患者中得到证实。还在后一组患者中评价了VPA对CLO药代动力学参数的影响。
The authors monitored the plasma levels of clobazam (CLO) and its principal metabolite, N-desmethylclobazam (NCLO) during chronic treatment of more than 400 epileptic patients receiving different co-medications, such as phenytoin (PH), carbamazepine (CBZ), sodium valproate (VPA) and phenobarbital (PB). This study investigated the influence of age and antiepileptic drugs on plasma levels of CLO and NCLO. Plasma concentrations measured 3 hr after morning administration of CLO varied from 30 to 700 [formula; see text] for CLO, and from 160 to 7000 [formula; see text] for NCLO. Plasma levels of CLO were higher in patients aged 20-30 years. NCLO concentrations increased with age up to 20 years. Coadministered antiepileptic compounds significantly decreased maximal plasma levels of CLO. Moreover, PH and CBZ a significantly increased the plasma levels of NCLO. Results on the influence of CBZ on CLO kinetics were confirmed in a group of ten patients receiving PB and VPA and later PB, VPA and CBZ as CLO associated drugs. The influence of VPA on the pharmacokinetics parameters of CLO was also evaluated in a patient in the latter group.