Association between pulse pressure and C-reactive protein among apparently healthy US adults
Association between pulse pressure and C-reactive protein among apparently healthy US adults
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DOI：
10.1161/hy0202.104270
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发表时间：
2002-02-01
期刊：
影响因子：
8.3
通讯作者：
Vaccarino, V
中科院分区：
文献类型：
--
作者：
Abramson, JL;Weintraub, WS;Vaccarino, V
脉压升高与心血管疾病的风险增加有关，心血管疾病越来越被视为炎症性疾病。因此，脉压升高和心血管疾病风险之间联系的潜在机制可能是炎症。然而，研究人员还没有研究脉压和C反应蛋白之间的关系，C反应蛋白是一种与心血管风险密切相关的炎症标志物。我们研究了9867名参加第三次全国健康与营养检查调查的17岁或17岁以上健康人的脉压和C反应蛋白之间的横断面关系。通过逻辑回归分析评估脉压和C反应蛋白水平升高（大于或等于0.66 mg/dL）的几率之间的关系。在调整收缩压、人口统计学因素、胆固醇、肥胖指标、吸烟、饮酒、体力活动和抗高血压药物使用的模型中，脉压增加10 mm Hg与C反应蛋白水平升高的几率增加15（比值比，1.15; 95%置信区间，1.01至1.31; P=0.04）。当调整舒张压而不是收缩压重新运行相同的模型时，脉压升高10 mm Hg与C反应蛋白水平升高的几率显著增加12%相关。一旦考虑到脉压，收缩压和舒张压与C反应蛋白无关。我们的研究结果表明，在表面健康的美国成年人中，脉压增加与C反应蛋白水平升高相关，与收缩压和舒张压无关。
Elevated pulse pressure has been associated with an increased risk of cardiovascular disease, which is increasingly being seen as an inflammatory disease. Thus, the mechanism underlying the link between elevated pulse pressure and cardiovascular disease risk may be inflammation. However, investigators have not examined the relationship between pulse pressure and C-reactive protein, an inflammation marker that has been closely linked to cardiovascular risk. We examined the cross-sectional relationship between pulse pressure and C-reactive protein among 9867 healthy persons 17 years of age or older who participated in the Third National Health and Nutrition Examination Survey. The association between pulse pressure and the odds of having an elevated C-reactive protein level (greater than or equal to0.66 mg/dL) was assessed by logistic regression. In a model that adjusted for systolic blood pressure, demographic factors, cholesterol, measures of obesity, smoking, alcohol consumption, physical activity, and antihypertensive medication use, a 10 mm Hg increase in pulse pressure was associated with a 15% increase in the odds of having an elevated C-reactive protein level (odds ratio, 1.15; 95% confidence interval, 1.01 to 1.31; P=0.04). When the same model was re-run adjusting for diastolic blood pressure instead of systolic blood pressure, a 10 mm Hg rise in pulse pressure was associated with a significant 12% increase in the odds of having an elevated C-reactive protein level. Systolic and diastolic blood pressure were unrelated to C-reactive protein once pulse pressure had been accounted for. Our results suggest that increases in pulse pressure are associated with elevated C-reactive protein levels among apparently healthy US adults, independent of systolic and diastolic blood pressure.