A PUTATIVE CELL SIGNAL ENCODED BY THE FOLDED GASTRULATION GENE COORDINATES CELL-SHAPE CHANGES DURING DROSOPHILA GASTRULATION
A PUTATIVE CELL SIGNAL ENCODED BY THE FOLDED GASTRULATION GENE COORDINATES CELL-SHAPE CHANGES DURING DROSOPHILA GASTRULATION
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DOI：
10.1016/0092-8674(94)90384-0
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发表时间：
1994-03-25
期刊：
影响因子：
64.5
通讯作者：
WIESCHAUS, E
中科院分区：
文献类型：
--
作者：
COSTA, M;WILSON, ET;WIESCHAUS, E
在果蝇原肠胚形成过程中，fold原肠胚形成（fog）基因是两个形态发生运动所必需的，即腹侧沟的形成和后中肠原基的内陷。Fog通过以空间和时间限定的方式诱导细胞的顶端收缩来协调这些内陷期间的细胞形状变化。雾在内陷原基中以一种模式表达，该模式恰好先于收缩模式。过量表达雾在背前区的胚胎诱导异位收缩，表明雾转录本的本地化可能定义域的细胞形状变化。FOG编码一种新的蛋白质，其具有推定的信号序列但没有潜在的跨膜结构域。我们建议雾功能作为一种分泌信号，激活G蛋白α亚基编码的手风琴在邻近的细胞。我们的分析表明，细胞间的通讯确保了收缩起始从内陷原基中间向边缘的快速、有序的进展。
The folded gastrulation (fog) gene is required during Drosophila gastrulation for two morphogenetic movements, formation of the ventral furrow and invagination of the posterior midgut primordium. fog coordinates cell shape changes during these invaginations by inducing apical constriction of cells in spatially and temporally defined manners. fog is expressed in the invagination primordia in a pattern that precisely precedes the pattern of constrictions. Overexpression of fog in the dorsoanterior region of the embryo induces ectopic constrictions, indicating localization of fog transcripts may define domains of cell shape changes. fog encodes a novel protein with a putative signal sequence but no potential transmembrane domains. We suggest fog functions as a secreted signal that activates the G protein alpha subunit encoded by concertina in neighboring cells. Our analyses indicate that cell-cell communication ensures the rapid, orderly progression of constriction initiations from the middle of invagination primordia out toward the margins.